Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, China.
Eur Eat Disord Rev. 2012 Nov;20(6):439-50. doi: 10.1002/erv.2197. Epub 2012 Sep 4.
The characteristics of the cognitive processing of food, body and emotional information in patients with anorexia nervosa (AN) are debatable. We reviewed functional magnetic resonance imaging studies to assess whether there were consistent neural basis and networks in the studies to date. Searching PubMed, Ovid, Web of Science, The Cochrane Library and Google Scholar between January 1980 and May 2012, we identified 17 relevant studies. Activation likelihood estimation was used to perform a quantitative meta-analysis of functional magnetic resonance imaging studies. For both food stimuli and body stimuli, AN patients showed increased hemodynamic response in the emotion-related regions (frontal, caudate, uncus, insula and temporal) and decreased activation in the parietal region. Although no robust brain activation has been found in response to emotional stimuli, emotion-related neural networks are involved in the processing of food and body stimuli among AN. It suggests that negative emotional arousal is related to cognitive processing bias of food and body stimuli in AN.
神经性厌食症（AN）患者对食物、身体和情绪信息的认知加工特点存在争议。我们综述了功能磁共振成像研究，以评估目前的研究是否存在一致的神经基础和网络。检索 1980 年 1 月至 2012 年 5 月期间的 PubMed、Ovid、Web of Science、The Cochrane Library 和 Google Scholar，我们共识别出 17 项相关研究。采用激活似然估计对功能磁共振成像研究进行定量荟萃分析。对于食物刺激和身体刺激，AN 患者在与情绪相关的区域（额叶、尾状核、钩回、岛叶和颞叶）显示出更高的血液动力学反应，而在顶叶区域显示出更低的激活。尽管针对情绪刺激尚未发现明显的大脑激活，但情绪相关神经网络参与了 AN 患者对食物和身体刺激的加工。这表明，负性情绪唤醒与 AN 患者对食物和身体刺激的认知加工偏向有关。
