Norrlin Lara, Baumann Oliver
School of Psychology, Bond University, Gold Coast, QLD 4226, Australia.
Int J Environ Res Public Health. 2025 Jan 1;22(1):55. doi: 10.3390/ijerph22010055.
Body image concerns are key prognostic and pathogenic factors of anorexia nervosa (AN) and bulimia nervosa (BN). This study aimed to investigate the neural mechanisms underlying body image perception across its two domains of estimation and satisfaction in anorexia and bulimia patients and healthy controls (HC). Systematic searches were conducted across eight databases, including PubMed; Cochrane Library; Ovid; Google Scholar; Sage Journals; Scopus; PsycInfo; and ScienceDirect, from database inception until the 23rd of April 2023. The sample pertained to 14 functional magnetic resonance imaging (fMRI) studies and 556 participants, with tasks primarily including image and silhouette-based body estimation and satisfaction paradigms. ALE meta-analysis was conducted to investigate significant clusters of activation foci across the different studies. Shared activations were observed between HC, AN, and BN patients in cortical regions related to object manipulation and recognition, visuospatial awareness, and memory and negative affect regulation. Differential activation in interoceptive and higher-order cognitive or affective control regions likely hold the key to pathological body distortion. This study outlined commonalities and differences in the correlates driving healthy body mapping and eating disorder pathology. Our findings provide pertinent implications for future research, current clinical interventions, and therapeutic outcomes.
身体意象问题是神经性厌食症（AN）和神经性贪食症（BN）的关键预后因素和致病因素。本研究旨在探究神经性厌食症和神经性贪食症患者以及健康对照者（HC）在身体意象感知的两个方面（估计和满意度）背后的神经机制。从数据库建立到2023年4月23日，对八个数据库进行了系统检索，包括PubMed、Cochrane图书馆、Ovid、谷歌学术、Sage期刊、Scopus、PsycInfo和ScienceDirect。样本涉及14项功能磁共振成像（fMRI）研究和556名参与者，任务主要包括基于图像和轮廓的身体估计及满意度范式。进行了激活可能性估计（ALE）元分析，以研究不同研究中激活焦点的显著聚类。在与物体操作和识别、视觉空间意识、记忆以及消极情绪调节相关的皮质区域，健康对照者、神经性厌食症患者和神经性贪食症患者之间观察到了共同激活。内感受和高阶认知或情感控制区域的差异激活可能是病理性身体扭曲的关键。本研究概述了驱动健康身体映射和饮食失调病理的相关因素的共性和差异。我们的研究结果对未来研究、当前临床干预和治疗结果具有重要意义。
