镍催化的对甲苯磺酸盐与格氏试剂的 Kumada 反应，生成烯烃和改性芳基酮。
Nickel-catalyzed Kumada reaction of tosylalkanes with Grignard reagents to produce alkenes and modified arylketones.
机构信息
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China.
出版信息
Angew Chem Int Ed Engl. 2012 Sep 24;51(39):9909-13. doi: 10.1002/anie.201205969. Epub 2012 Sep 3.
PMID:22945894
Abstract
Open a new door: The first example of alkene synthesis from alkyl electrophiles with Grignard reagents using the Kumada cross-coupling reaction strategy is reported. This method opens a new door for the Kumada cross-coupling reaction, allowing alkenes to be prepared from the reaction of tosylalkanes with Grignard reagents.
摘要
开辟新途径
本文首次报道了利用 Kumada 交叉偶联反应策略，由格氏试剂与烷基亲电试剂合成烯烃。该方法为 Kumada 交叉偶联反应开辟了新途径，使烯烃能够由对甲苯磺酸烷基与格氏试剂的反应来制备。
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