Pusan National University, Department of Chemistry, Pusan 609-735, Korea.
Org Lett. 2012 Sep 21;14(18):4790-3. doi: 10.1021/ol302086v. Epub 2012 Sep 4.
The catalytic regioselective hydroboration of propargylic alcohols and ethers was investigated using NHC-CuCl. We observe that different NHC-CuCl complexes catalyze hydroborations of propargylic substrates with opposite regioselectivity. A 6-NHC-CuCl complex provides α-selectivity whereas β-selectivity is achieved using a 5-NHC-CuCl complex. The reaction tolerates a wide range of functional groups.
我们使用 NHC-CuCl 研究了丙炔醇和醚的催化区域选择性硼氢化反应。我们观察到不同的 NHC-CuCl 配合物催化丙炔基底物的硼氢化反应具有相反的区域选择性。6-NHC-CuCl 配合物提供 α-选择性，而 5-NHC-CuCl 配合物则实现 β-选择性。该反应能耐受广泛的官能团。
