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大孔 PHEMA 基胆红素清除水凝胶盘。

Macroporous PHEMA-based cryogel discs for bilirubin removal.

机构信息

Department of Biology, Molecular Biology Division, Hacettepe University, Ankara, Turkey.

出版信息

Artif Cells Nanomed Biotechnol. 2013 Jun;41(3):172-7. doi: 10.3109/10731199.2012.712046. Epub 2012 Sep 4.

DOI:10.3109/10731199.2012.712046
PMID:22947178
Abstract

A novel N-methacryloyl-L-tryptophan methyl ester (MATrp) containing poly (hydroxyethyl methacrylate) cryogel (PHEMATrp) disc was prepared for removal of bilirubin (BR) out of human plasma. PHEMATrp cryogel disc was produced by bulk polymerization, with high gelation yield up to 92% and characterized by swelling tests, scanning electron microscopy (SEM), elemental analysis, Brunauer- Emmett-Teller (BET) analysis, contact angle measurements and surface energy calculations. BR adsorption studies were performed in a batch system, and the maximum BR adsorption capacity was found as 22.2 mg/g cryogel disc.

摘要

一种新型的 N-丙烯酰基-L-色氨酸甲酯(MATrp)含有聚(羟乙基甲基丙烯酸酯)水凝胶(PHEMATrp)圆盘,用于从人血浆中去除胆红素(BR)。PHEMATrp 水凝胶圆盘通过本体聚合制备,凝胶产率高达 92%,并通过溶胀试验、扫描电子显微镜(SEM)、元素分析、Brunauer-Emmett-Teller(BET)分析、接触角测量和表面能计算进行了表征。BR 吸附研究在间歇系统中进行,发现最大 BR 吸附容量为 22.2mg/g 水凝胶圆盘。

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