Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China.
Int J Neurosci. 2013 Jan;123(1):60-4. doi: 10.3109/00207454.2012.726669. Epub 2012 Oct 8.
Vitamin D and vitamin D receptor (VDR) have been postulated as environmental and genetic factors in neurodegenerative disorders including multiple sclerosis, Alzheimer disease, and recently Parkinson disease (PD). The purpose of this study is to explore the potential correlation between single nucleotide polymorphisms of the VDR gene (VDR) rs4334089 and rs731236 and PD. A total of 483 patients with PD and 498 age- and sex-matched controls were involved in this study. Genotypes were determined by using polymerase chain reaction-restriction fragment length polymorphism and DNA sequencing. There were no significant differences in the genotype and allele frequencies of VDR rs4334089 and rs731236 polymorphisms between the group of patients with PD and the control group in a Chinese Han population (for VDR rs4334089: OR 1.02, 95% CI: 0.85-1.23; for VDR rs731236: OR 1.13, 95% CI: 0.75-1.71). Similarly, there were still no differences when stratifying by age or by gender. These findings suggest that VDR gene is not a susceptibility gene for PD in our population.
维生素 D 和维生素 D 受体（VDR）被认为是包括多发性硬化症、阿尔茨海默病以及最近的帕金森病（PD）在内的神经退行性疾病的环境和遗传因素。本研究旨在探讨 VDR 基因（VDR）rs4334089 和 rs731236 单核苷酸多态性与 PD 之间的潜在相关性。本研究共纳入 483 例 PD 患者和 498 名年龄和性别匹配的对照组。采用聚合酶链反应-限制性片段长度多态性和 DNA 测序法确定基因型。在中国汉族人群中，PD 患者组与对照组 VDR rs4334089 和 rs731236 多态性的基因型和等位基因频率无显著差异（对于 VDR rs4334089：OR 1.02，95%CI：0.85-1.23；对于 VDR rs731236：OR 1.13，95%CI：0.75-1.71）。同样，按年龄或性别分层后仍无差异。这些发现表明，在我们的人群中，VDR 基因不是 PD 的易感基因。
