Department of Biochemistry and Molecular Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan, China.
Biosci Trends. 2011;5(3):99-103. doi: 10.5582/bst.2011.v5.3.99.
An abundance of candidate genes have been reported as susceptibility factors for the risk of nasopharyngeal carcinoma (NPC). Vitamin D receptor (VDR) plays an important role in cellular differentiation and the control of proliferation in a variety of cell types. To our knowledge, however, no study has reported the relationship between the VDR and NPC. The purpose of this study is to explore the potential correlation between single-nucleotide polymorphisms of the VDR gene (VDR) Fok I and Bsm I and NPC. A total of 171 patients with NPC and 176 age- and sex-matched controls were involved in this study. Genotypes were determined by using polymerase chain reaction-restriction fragment length polymorphism and DNA sequencing. There were no significant differences in the genotype and allele frequencies of VDR Fok I and Bsm I polymorphisms between the group of patients with NPC and the control group in a Chinese Han population (for VDR Fok I: adjusted OR 1.03, 95% CI: 0.76-1.41; for VDR Bsm I: adjusted OR 0.80, 95% CI: 0.48-1.33). Further studies will be needed to explore the complicated gene-gene interaction and gene-environmental interactions in the susceptibility to NPC, especially in ethnically disparate populations in cohort study samples.
大量候选基因已被报道为鼻咽癌（NPC）风险的易感因素。维生素 D 受体（VDR）在多种细胞类型的细胞分化和增殖控制中发挥重要作用。然而，据我们所知，尚无研究报道 VDR 与 NPC 之间的关系。本研究旨在探讨 VDR 基因（VDR）Fok I 和 Bsm I 单核苷酸多态性与 NPC 之间的潜在相关性。本研究共纳入 171 例 NPC 患者和 176 例年龄和性别匹配的对照。采用聚合酶链反应-限制性片段长度多态性和 DNA 测序法确定基因型。在中国汉族人群中，NPC 患者组与对照组之间 VDR Fok I 和 Bsm I 多态性的基因型和等位基因频率无显著差异（对于 VDR Fok I：调整后的 OR 为 1.03，95%CI：0.76-1.41；对于 VDR Bsm I：调整后的 OR 为 0.80，95%CI：0.48-1.33）。需要进一步的研究来探讨 NPC 易感性中的复杂基因-基因相互作用和基因-环境相互作用，特别是在队列研究样本中不同种族的人群。
