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Quantification of the anti-influenza drug zanamivir in plasma using high-throughput HILIC-MS/MS.使用高通量亲水相互作用色谱-串联质谱法对血浆中的抗流感药物扎那米韦进行定量分析。
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2
Chromatographic behavior of xanthines in aqueous normal phase chromatography using titania stationary phase.采用 TiO2 固定相的水相正相色谱法中黄嘌呤类的色谱行为。
J Chromatogr A. 2011 Feb 4;1218(5):721-5. doi: 10.1016/j.chroma.2010.12.016. Epub 2010 Dec 13.
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Aqueous normal phase chromatography improves quantification and qualification of homocysteine, cysteine and methionine by liquid chromatography-tandem mass spectrometry.水相正相色谱法通过液相色谱-串联质谱法提高同型半胱氨酸、半胱氨酸和蛋氨酸的定量和定性分析。
J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Jan 1;879(1):83-9. doi: 10.1016/j.jchromb.2010.11.016. Epub 2010 Nov 21.
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Our favorite materials: silica hydride stationary phases.我们最爱的材料：硅氢化物固定相。
J Sep Sci. 2009 Dec;32(23-24):3999-4011. doi: 10.1002/jssc.200900568.
5
Analysis of hydrophilic metabolites in physiological fluids by HPLC-MS using a silica hydride-based stationary phase.
J Sep Sci. 2009 Jul;32(13):2200-8. doi: 10.1002/jssc.200900270.
6
Aqueous normal-phase retention of nucleotides on silica hydride columns.核苷酸在氢化硅胶柱上的水相正相保留。
J Chromatogr A. 2009 Feb 13;1216(7):1140-6. doi: 10.1016/j.chroma.2008.12.046. Epub 2008 Dec 25.
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Analysis of hydrophilic metabolites by high-performance liquid chromatography-mass spectrometry using a silica hydride-based stationary phase.使用基于氢化硅的固定相通过高效液相色谱-质谱联用技术分析亲水性代谢物。
J Chromatogr A. 2008 Sep 12;1204(1):48-55. doi: 10.1016/j.chroma.2008.07.077. Epub 2008 Jul 31.
8
Surveillance for neuraminidase inhibitor resistance among human influenza A and B viruses circulating worldwide from 2004 to 2008.2004年至2008年全球流行的甲型和乙型人流感病毒中神经氨酸酶抑制剂耐药性监测
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9
Potential of HILIC-MS in quantitative bioanalysis of drugs and drug metabolites.亲水作用色谱-质谱联用技术在药物及药物代谢产物定量生物分析中的应用潜力
J Sep Sci. 2008 May;31(9):1481-91. doi: 10.1002/jssc.200700451.
10
Determination of zanamivir in rat and monkey plasma by positive ion hydrophilic interaction chromatography (HILIC)/tandem mass spectrometry.采用正离子亲水作用色谱（HILIC）/串联质谱法测定大鼠和猴血浆中的扎那米韦。
J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Jun 1;852(1-2):505-11. doi: 10.1016/j.jchromb.2007.02.006. Epub 2007 Feb 15.

水相正相液相色谱-串联飞行时间四极杆质谱法测定人血清中扎那米韦。

Aqueous normal phase liquid chromatography coupled with tandem time-of-flight quadrupole mass spectrometry for determination of zanamivir in human serum.

机构信息

Department of Molecular Biosciences and Bioengineering, University of Hawaii at Manoa, HI 96822, USA.

出版信息

J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Oct 1;906:58-62. doi: 10.1016/j.jchromb.2012.08.020. Epub 2012 Aug 21.

DOI:10.1016/j.jchromb.2012.08.020
PMID:22947416
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3465458/
Abstract

An aqueous normal phase (ANP) liquid chromatography coupled with a hybrid quadrupole time-of-flight mass spectrometry (ANP-LC-micrOTOFQ) method was used for the determination of zanamivir in human serum. Zanamivir was extracted with methanol from protein-precipitated human serum samples and further purified with SCX solid-phase extraction cartridges. Scherzo SM-C18, Agilent Zorbax SB-Aq, Cogent Diamond Hydride, Cogent Bidentate and Luna HILIC columns were compared and optimized for the retention and separation of zanamivir and the Luna HILIC and Diamond Hydride columns exhibited the best retention of zanamivir. The former provided a shorter retention time, a sharper peak and relatively high sensitivity, whereas the latter exhibited a longer retention time and less matrix interference. The analytical range of the calibration curve was between 5 and 1000 ng/mL.

摘要

采用水相正相（ANP）液相色谱-混合四极杆飞行时间质谱（ANP-LC-micrOTOFQ）法测定人血清中的扎那米韦。扎那米韦从蛋白沉淀的人血清样品中用甲醇提取，并用 SCX 固相萃取小柱进一步纯化。对 Scherzo SM-C18、Agilent Zorbax SB-Aq、Cogent Diamond Hydride、Cogent Bidentate 和 Luna HILIC 柱进行了比较和优化，以实现扎那米韦的保留和分离，其中 Luna HILIC 和 Diamond Hydride 柱对扎那米韦的保留效果最好。前者提供了较短的保留时间、更尖锐的峰和相对较高的灵敏度，而后者则具有较长的保留时间和较少的基质干扰。校准曲线的分析范围为 5 至 1000ng/mL。