α-珠蛋白基因标记揭示了澳大利亚原住民和美拉尼西亚人之间的遗传差异。
Alpha-globin gene markers identify genetic differences between Australian aborigines and Melanesians.
作者信息
Tsintsof A S, Hertzberg M S, Prior J F, Mickleson K N, Trent R J
机构信息
Clinical Immunology Research Centre, University of Sydney, New South Wales, Australia.
出版信息
Am J Hum Genet. 1990 Jan;46(1):138-43.
Abstract
Australian aborigines exhibit a number of alpha-globin cluster rearrangements involving both alpha- and zeta-globin genes. alpha+-Thalassemia (-alpha/) in this population is heterogeneous and includes the 3.7 types I, II, and III gene deletions. The alpha alpha alpha/ and zeta zeta zeta/ rearrangements are each found in association with two haplotypes, indicating origins from at least two separate DNA crossover events. Differences in alpha-globin cluster rearrangements and in haplotypes between Australian aborigines, Papua New Guinea highlanders and island Melanesians, are consistent with multiple colonizing events into Australia.
摘要
澳大利亚原住民表现出许多涉及α-珠蛋白和ζ-珠蛋白基因的α-珠蛋白基因簇重排。该人群中的α+-地中海贫血（-α/）具有异质性，包括3.7型I、II和III基因缺失。ααα/和ζζζ/重排分别与两种单倍型相关联，表明它们起源于至少两个独立的DNA交叉事件。澳大利亚原住民、巴布亚新几内亚高地人和美拉尼西亚岛民之间α-珠蛋白基因簇重排和单倍型的差异，与多次向澳大利亚的殖民事件相一致。
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本文引用的文献
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