Tsintsof A S, Hertzberg M S, Prior J F, Mickleson K N, Trent R J
Clinical Immunology Research Centre, University of Sydney, New South Wales, Australia.
Am J Hum Genet. 1990 Jan;46(1):138-43.
Australian aborigines exhibit a number of alpha-globin cluster rearrangements involving both alpha- and zeta-globin genes. alpha+-Thalassemia (-alpha/) in this population is heterogeneous and includes the 3.7 types I, II, and III gene deletions. The alpha alpha alpha/ and zeta zeta zeta/ rearrangements are each found in association with two haplotypes, indicating origins from at least two separate DNA crossover events. Differences in alpha-globin cluster rearrangements and in haplotypes between Australian aborigines, Papua New Guinea highlanders and island Melanesians, are consistent with multiple colonizing events into Australia.
澳大利亚原住民表现出许多涉及α-珠蛋白和ζ-珠蛋白基因的α-珠蛋白基因簇重排。该人群中的α+-地中海贫血（-α/）具有异质性，包括3.7型I、II和III基因缺失。ααα/和ζζζ/重排分别与两种单倍型相关联，表明它们起源于至少两个独立的DNA交叉事件。澳大利亚原住民、巴布亚新几内亚高地人和美拉尼西亚岛民之间α-珠蛋白基因簇重排和单倍型的差异，与多次向澳大利亚的殖民事件相一致。
