人类胚胎ζ珠蛋白基因的多种排列方式。
Multiple arrangements of the human embryonic zeta globin genes.
作者信息
Winichagoon P, Higgs D R, Goodbourn S E, Lamb J, Clegg J B, Weatherall D J
出版信息
Nucleic Acids Res. 1982 Oct 11;10(19):5853-68. doi: 10.1093/nar/10.19.5853.
Abstract
Rearrangements which are most readily explained by homologous crossover between misaligned segments of DNA in the region of the human embryonic zeta (zeta) globin genes have been identified in individuals of three different racial origins. These recombination events have resulted in a surprisingly high prevalence of chromosomes with single (0.4%) and triplicated (1.3%) zeta genes with apparently no significant effect on the phenotype.
摘要
在三个不同种族来源的个体中，已鉴定出最容易通过人类胚胎ζ珠蛋白基因区域中DNA错位片段之间的同源交叉来解释的重排。这些重组事件导致单拷贝（0.4%）和三拷贝（1.3%）ζ基因的染色体出现率惊人地高，而对表型显然没有显著影响。
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