Nikander R, Sievänen H, Ojala K, Kellokumpu-Lehtinen P-L, Palva T, Blomqvist C, Luoto R, Saarto T
Helsinki Metropolia University, Department of Physiotherapy, Helsinki, Finland.
J Musculoskelet Neuronal Interact. 2012 Sep;12(3):127-35.
In this 12-month RCT, we examined whether aerobic impact exercise training (3x/week) could facilitate breast cancer survivors' recovery by enhancing their bone structural strength, physical performance and body composition. After the adjuvant chemo- and/ or radiotherapy, 86 patients were randomly assigned into the training or control group. Structural bone traits were assessed with pQCT at the tibia and with DXA at the femoral neck. Agility (figure-8 running), jump force and power (force platform), grip strength and cardiovascular fitness (2-km walk test) were also assessed. Training effects on outcome variables were estimated by two-way factorial ANCOVA using the study group and menopausal status as fixed factors. Bone structural strength was better maintained among the trainees. At the femoral neck, there was a small but significant 2% training effect in the bone mass distribution (p=0.05). At the tibial diaphysis, slight 1% to 2% training effects (p=0.03) in total cross-sectional area and bone structural strength were observed (p=0.03) among the postmenopausal trainees. Also, 3% to 4% training effects were observed in the figure-8 running time (p=0.03) and grip strength (p=0.01). In conclusion, vigorous aerobic impact exercise training has potential to maintain bone structural strength and improve physical performance among breast cancer survivors.
在这项为期12个月的随机对照试验中，我们研究了有氧冲击运动训练（每周3次）是否能通过增强乳腺癌幸存者的骨骼结构强度、身体机能和身体成分来促进其恢复。在辅助化疗和/或放疗后，86名患者被随机分为训练组或对照组。使用外周定量计算机断层扫描（pQCT）评估胫骨的骨骼结构特征，使用双能X线吸收法（DXA）评估股骨颈的骨骼结构特征。还评估了敏捷性（8字跑）、跳跃力和功率（测力平台）、握力和心血管健康状况（2公里步行测试）。使用研究组和绝经状态作为固定因素，通过双向析因协方差分析估计训练对结果变量的影响。训练组的骨骼结构强度得到了更好的维持。在股骨颈处，骨量分布有一个虽小但显著的2%的训练效果（p=0.05）。在绝经后训练组的胫骨骨干处，观察到总横截面积和骨骼结构强度有轻微的1%至2%的训练效果（p=0.03）（p=0.03）。此外，在8字跑时间（p=0.03）和握力（p=0.01）方面观察到3%至4%的训练效果。总之，剧烈的有氧冲击运动训练有潜力维持乳腺癌幸存者的骨骼结构强度并改善其身体机能。
