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Enterococcus faecalis pheromone binding protein, PrgZ, recruits a chromosomal oligopeptide permease system to import sex pheromone cCF10 for induction of conjugation.粪肠球菌信息素结合蛋白PrgZ招募一种染色体寡肽通透酶系统来导入性信息素cCF10以诱导接合作用。
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Two ABC transport systems carry out peptide uptake in Enterococcus faecalis: Their roles in growth and in uptake of sex pheromones.两种 ABC 转运系统在粪肠球菌中进行肽吸收：它们在生长和性信息素吸收中的作用。
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Analysis of the amino acid sequence specificity determinants of the enterococcal cCF10 sex pheromone in interactions with the pheromone-sensing machinery.肠球菌cCF10性信息素与信息素感应机制相互作用中氨基酸序列特异性决定因素的分析
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本文引用的文献

1
Escherichia coli peptide binding protein OppA has a preference for positively charged peptides.大肠杆菌肽结合蛋白 OppA 对带正电荷的肽具有偏好性。
J Mol Biol. 2011 Nov 18;414(1):75-85. doi: 10.1016/j.jmb.2011.09.043. Epub 2011 Oct 1.
2
Compensating stereochemical changes allow murein tripeptide to be accommodated in a conventional peptide-binding protein.补偿立体化学变化使得肽聚糖三肽能够适应常规的肽结合蛋白。
J Biol Chem. 2011 Sep 9;286(36):31512-21. doi: 10.1074/jbc.M111.267179. Epub 2011 Jun 24.
3
Importance of a hydrophobic pocket for peptide binding in lactococcal OppA.乳球菌 OppA 中疏水性口袋对肽结合的重要性。
J Bacteriol. 2011 Aug;193(16):4254-6. doi: 10.1128/JB.00447-11. Epub 2011 Jun 10.
4
A structural classification of substrate-binding proteins.底物结合蛋白的结构分类。
FEBS Lett. 2010 Jun 18;584(12):2606-17. doi: 10.1016/j.febslet.2010.04.043. Epub 2010 Apr 20.
5
Direct evidence for control of the pheromone-inducible prgQ operon of Enterococcus faecalis plasmid pCF10 by a countertranscript-driven attenuation mechanism.直接证据表明，粪肠球菌质粒 pCF10 的信息素诱导的 prgQ 操纵子受到反义转录物驱动的衰减机制的控制。
J Bacteriol. 2010 Mar;192(6):1634-42. doi: 10.1128/JB.01525-09. Epub 2010 Jan 22.
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MolProbity: all-atom structure validation for macromolecular crystallography.MolProbity：用于大分子晶体学的全原子结构验证
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7
The structural basis for peptide selection by the transport receptor OppA.转运受体OppA选择肽段的结构基础。
EMBO J. 2009 May 6;28(9):1332-40. doi: 10.1038/emboj.2009.65. Epub 2009 Mar 19.
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Automated macromolecular model building for X-ray crystallography using ARP/wARP version 7.使用ARP/wARP 7版本进行X射线晶体学的自动化大分子模型构建。
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BALBES: a molecular-replacement pipeline.BALBES：一种分子置换流程。
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High-throughput cloning and expression in recalcitrant bacteria.在难培养细菌中的高通量克隆与表达
Nat Methods. 2007 Sep;4(9):705-7. doi: 10.1038/nmeth1073. Epub 2007 Jul 22.

信息素受体 PrgZ 的肽结合结构和模式。

Structure and mode of peptide binding of pheromone receptor PrgZ.

机构信息

Department of Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, Netherlands Proteomics Centre, University of Groningen, 9747 AG Groningen, The Netherlands.

出版信息

J Biol Chem. 2012 Oct 26;287(44):37165-70. doi: 10.1074/jbc.M112.386334. Epub 2012 Sep 4.

DOI:10.1074/jbc.M112.386334
PMID:22948145
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3481316/
Abstract

We present the crystal structure of the pheromone receptor protein PrgZ from Enterococcus faecalis in complex with the heptapeptide cCF10 (LVTLVFV), which is used in signaling between conjugative recipient and donor cells. Comparison of PrgZ with homologous oligopeptide-binding proteins (AppA and OppA) explains the high specificity of PrgZ for hydrophobic heptapeptides versus the promiscuity of peptide binding in the homologous proteins.

摘要

我们展示了来自粪肠球菌的信息素受体蛋白 PrgZ 与七肽 cCF10（LVTLVFV）复合物的晶体结构，该七肽用于在接合受体和供体细胞之间进行信号传递。PrgZ 与同源寡肽结合蛋白（AppA 和 OppA）的比较解释了 PrgZ 对疏水性七肽的高特异性，而同源蛋白中肽结合的混杂性。