Department of Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, The Netherlands.
FEBS Lett. 2010 Jun 18;584(12):2606-17. doi: 10.1016/j.febslet.2010.04.043. Epub 2010 Apr 20.
Substrate-binding proteins (SBP) are associated with a wide variety of protein complexes. The proteins are part of ATP-binding cassette transporters for substrate uptake, ion gradient driven transporters, DNA-binding proteins, as well as channels and receptors from both pro- and eukaryotes. A wealth of structural and functional data is available on SBPs, with over 120 unique entries in the Protein Data Bank (PDB). Over a decade ago these proteins were divided into three structural classes, but based on the currently available wealth of structural data, we propose a new classification into six clusters, based on features of their three-dimensional structure.
基质结合蛋白 (SBP) 与多种蛋白质复合物相关联。这些蛋白质是用于底物摄取的 ATP 结合盒转运蛋白、离子梯度驱动的转运蛋白、DNA 结合蛋白以及原核生物和真核生物的通道和受体的一部分。目前已经有大量关于 SBPs 的结构和功能数据，蛋白质数据库 (PDB) 中收录了超过 120 个独特的条目。十多年前，这些蛋白质被分为三个结构类别，但根据目前可用的大量结构数据，我们基于其三维结构的特征，提出了一种新的分类法，分为六个簇。
