Bredenkamp J K, Castro D J, Mickel R A
Department of Surgery, University of California, Los Angeles School of Medicine.
Ann Otol Rhinol Laryngol. 1990 Jan;99(1):51-4. doi: 10.1177/000348949009900109.
Plummer-Vinson syndrome (PVS) is characterized by iron deficiency anemia, upper esophageal stricture, cervical dysphagia, and glossitis. The precise role of iron deficiency in PVS has yet to be defined and remains a subject of much debate. A 29-year-old woman with PVS is presented. The patient had a 4-year history of severe iron deficiency anemia, a 2-year history of progressive dysphagia and weight loss, and a greater than 90% benign upper esophageal stricture. Iron therapy alone resolved her dysphagia and anemia, and a follow-up esophagram 1 year later showed a residual stenosis of less than 30%. The development of severe iron deficiency anemia in this patient 2 years before the onset of dysphagia, as well as the response of the stricture to iron repletion, supports the theory that iron deficiency can cause dysphagia and upper esophageal strictures. The occurrence of glossitis, gastritis, and esophagitis in iron deficiency demonstrates the adverse effects of iron depletion on the rapidly proliferating cells of the upper alimentary tract.
普卢默-文森综合征（PVS）的特征为缺铁性贫血、食管上段狭窄、颈部吞咽困难和舌炎。缺铁在PVS中的确切作用尚未明确，仍是诸多争论的主题。本文介绍了一名患有PVS的29岁女性。该患者有4年严重缺铁性贫血病史、2年进行性吞咽困难和体重减轻病史，且食管上段良性狭窄超过90%。仅铁剂治疗就缓解了她的吞咽困难和贫血，1年后的随访食管造影显示残余狭窄小于30%。该患者在吞咽困难发作前2年出现严重缺铁性贫血，以及狭窄对铁剂补充的反应，支持了缺铁可导致吞咽困难和食管上段狭窄的理论。缺铁时出现舌炎、胃炎和食管炎，表明铁缺乏对上消化道快速增殖细胞有不良影响。
