Department of Gastroenterology and Hepatology, Hedi Chaker University Hospital, Sfax 3089, Tunisia.
Sfax Medical School, University of Sfax, Sfax 3029, Tunisia.
Pan Afr Med J. 2023 Jan 11;44:21. doi: 10.11604/pamj.2023.44.21.35809. eCollection 2023.
Plummer Vinson syndrome (PVS) is a rare entity and most publications are case or series of cases. Thus, we report a series from southern Tunisia. Our aim was to analyse the epidemiological and clinical characteristics, the therapeutic modalities as well as the evolution of this pathology. Thus we carried out a retrospective study from 2009 until 2019. For each patient with PVS, we collected the epidemiological, clinical, paraclinical data and therapeutic modalities. A total of 23 patients were enrolled with a median age of 49.52 years [18-82 years] and a clear female predominance (M/F=2/21). The median duration of dysphagia was 42 months [4-92 months]. Moderate microcytic hypochromic anemia was noted in 16 patients. The anemia was without obvious cause in 60.8% (n=14) of cases. The main endoscopic finding was a diaphragm in the cervical area. Treatment was based on iron supplementation followed by endoscopic dilatation with Savary dilators in 90.9% (n=20) and balloons for 9.1% of patients (n=2). Dysphagia recurred in 5 patients after a median of 26.6 months [2-60 months]. Three cases of PVS were complicated by esophageal squamous cell carcinoma. In conclusion, our series confirms that PVS affects mostly women. Anemia is frequently noted in these patients. Treatment is based on endoscopic dilatation which is often an easy and risk-free procedure and iron supplementation.
普卢默-文森综合征（PVS）是一种罕见的疾病，大多数文献都是病例报告或病例系列。因此，我们报告了来自突尼斯南部的一系列病例。我们的目的是分析该疾病的流行病学和临床特征、治疗方式以及演变过程。为此，我们进行了一项回顾性研究，时间范围为 2009 年至 2019 年。对于每例 PVS 患者，我们收集了流行病学、临床和实验室数据以及治疗方式。共纳入 23 例患者，中位年龄为 49.52 岁[18-82 岁]，女性明显多于男性（M/F=2/21）。吞咽困难的中位持续时间为 42 个月[4-92 个月]。16 例患者存在中度小细胞低色素性贫血。60.8%（n=14）的贫血无明显原因。主要的内镜发现是颈段食管膈。治疗方法是铁剂补充，90.9%（n=20）的患者随后进行内镜扩张（Savary 扩张器），9.1%的患者（n=2）使用球囊。中位随访 26.6 个月[2-60 个月]后，5 例患者出现吞咽困难复发。3 例 PVS 患者并发食管鳞状细胞癌。总之，我们的系列研究证实 PVS 主要影响女性。这些患者常伴有贫血。治疗方法是基于内镜扩张，这通常是一种简单且无风险的方法，同时还需要补充铁剂。
