Forjaz C L M, Bartholomeu T, Rezende J A S, Oliveira J A, Basso L, Tani G, Prista A, Maia J A R
Laboratório de Hemodinâmica da Atividade Motora (LAHAM), Escola de Educação Física e Esporte, Universidade de São Paulo, São Paulo, SP, Brasil.
Braz J Med Biol Res. 2012 Dec;45(12):1269-75. doi: 10.1590/s0100-879x2012007500141. Epub 2012 Sep 6.
Blood pressure (BP) and physical activity (PA) levels are inversely associated. Since genetic factors account for the observed variation in each of these traits, it is possible that part of their association may be related to common genetic and/or environmental influences. Thus, this study was designed to estimate the genetic and environmental correlations of BP and PA phenotypes in nuclear families from Muzambinho, Brazil. Families including 236 offspring (6 to 24 years) and their 82 fathers and 122 mothers (24 to 65 years) were evaluated. BP was measured, and total PA (TPA) was assessed by an interview (commuting, occupational, leisure time, and school time PA). Quantitative genetic modeling was used to estimate maximal heritability (h²), and genetic and environmental correlations. Heritability was significant for all phenotypes (systolic BP: h² = 0.37 ± 0.10, P < 0.05; diastolic BP: h² = 0.39 ± 0.09, P < 0.05; TPA: h² = 0.24 ± 0.09, P < 0.05). Significant genetic (r g) and environmental (r e) correlations were detected between systolic and diastolic BP (r g = 0.67 ± 0.12 and r e = 0.48 ± 0.08, P < 0.05). Genetic correlations between BP and TPA were not significant, while a tendency to an environmental cross-trait correlation was found between diastolic BP and TPA (r e = -0.18 ± 0.09, P = 0.057). In conclusion, BP and PA are under genetic influences. Systolic and diastolic BP share common genes and environmental influences. Diastolic BP and TPA are probably under similar environmental influences.
血压（BP）与身体活动（PA）水平呈负相关。由于遗传因素解释了这些性状各自观察到的变异，它们之间关联的一部分可能与共同的遗传和/或环境影响有关。因此，本研究旨在估计巴西穆赞比尼奥核心家庭中BP和PA表型的遗传和环境相关性。对包括236名后代（6至24岁）及其82名父亲和122名母亲（24至65岁）的家庭进行了评估。测量了血压，并通过访谈（通勤、职业、休闲时间和上学时间的身体活动）评估了总身体活动（TPA）。采用定量遗传模型来估计最大遗传力（h²）以及遗传和环境相关性。所有表型的遗传力均显著（收缩压：h² = 0.37 ± 0.10，P < 0.05；舒张压：h² = 0.39 ± 0.09，P < 0.05；TPA：h² = 0.24 ± 0.09，P < 0.05）。在收缩压和舒张压之间检测到显著的遗传（rg）和环境（re）相关性（rg = 0.67 ± 0.12，re = 0.48 ± 0.08，P < 0.05）。BP与TPA之间的遗传相关性不显著，而在舒张压与TPA之间发现了环境跨性状相关的趋势（re = -0.18 ± 0.09，P = 0.057）。总之，BP和PA受遗传影响。收缩压和舒张压共享共同的基因和环境影响。舒张压和TPA可能受相似的环境影响。
