Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
BMC Public Health. 2023 Mar 13;23(1):474. doi: 10.1186/s12889-023-15397-1.
As reported, hypertension (HTN) plays a leading role in explaining mortality worldwide, but it still has many confounding factors. This study explored whether the number of parity and age matters for HTN among couples from the Tehran Lipid and Glucose Study (TLGS).
This study was conducted on 2851 couples from TLGS. All the variables were collected based on the standard protocol. The participants were categorized into four and five categories according to the number of parity (childless, one, two, three, or more parities) and age (18-30y, 30-40y, 40-50y, 50-60y, and 60-70y), respectively. Spline regression models via log link function for the binary outcome and linear link function for continuous outcomes were applied to evaluate the effect of interaction term age and parity categories on the desired outcome.
Among the total of 2851 pairs, 2.3% had no child, 9.5% had 1 child, 38.4% had 2 children, and 49.8% had ≥ 3 children. The adjusted risk (95% CI) of HTN in females aged 40-50y with 1 child, 2 and ≥ 3 children compared to no child were 1.14(1.04, 1.26), 1.05(1.01, 1.10), 1.12(1.07, 1.17), respectively (p < 0.05). Moreover, in those aged 50-60y with 2 and ≥ 3 children, the risk of HTN significantly increased by 4%. In females aged 60-70y with ≥ 3 children compared to those without children, the risk of HTN increased by 2%. For males aged 30-40y with 2 children compared to the no child group, the adjusted risk of HTN increased by 17%, while for those with ≥ 3 children in the same age group, this risk significantly decreased by 13%. Moreover, in males aged 30-40y with 2 children, risk ratio of HTN increased by 17%, but in males with ≥ 3 children, it decreased by 13% and in those in the same groups but aged 40-50y the risk increased by 6% and 11%, respectively.
Our findings suggest that gender, childlessness, having one child, and multi-parity had different impacts on HTN. Further research is needed to confirm our findings.
据报道，高血压（HTN）在全球范围内导致的死亡率中占主导地位，但它仍有许多混杂因素。本研究旨在探讨来自德黑兰血脂和血糖研究（TLGS）的夫妇中，生育次数和年龄是否对 HTN 有影响。
本研究纳入了 2851 对来自 TLGS 的夫妇。所有变量均根据标准方案收集。根据生育次数（无子女、1 个、2 个、3 个或更多个子女）和年龄（18-30 岁、30-40 岁、40-50 岁、50-60 岁和 60-70 岁），将参与者分别分为四组和五组。对于二分类结局，采用对数链接函数的样条回归模型和线性链接函数的连续结局，以评估交互项年龄和生育次数组别的效应。
在总共 2851 对夫妇中，2.3%的夫妇没有子女，9.5%的夫妇有 1 个孩子，38.4%的夫妇有 2 个孩子，49.8%的夫妇有≥3 个孩子。与无子女的女性相比，年龄在 40-50 岁、生育 1 个孩子、2 个孩子和≥3 个孩子的女性患 HTN 的调整风险（95%CI）分别为 1.14（1.04，1.26）、1.05（1.01，1.10）、1.12（1.07，1.17）（p<0.05）。此外，年龄在 50-60 岁、生育 2 个和≥3 个孩子的女性患 HTN 的风险分别增加了 4%和 4%。年龄在 60-70 岁、生育≥3 个孩子的女性与无子女的女性相比，患 HTN 的风险增加了 2%。年龄在 30-40 岁、生育 2 个孩子的男性与无子女的男性相比，患 HTN 的调整风险增加了 17%，而在同一年龄组生育≥3 个孩子的男性患 HTN 的风险显著降低了 13%。此外，年龄在 30-40 岁、生育 2 个孩子的男性患 HTN 的风险比增加了 17%，而生育≥3 个孩子的男性患 HTN 的风险比降低了 13%，而在同一组但年龄在 40-50 岁的男性，患 HTN 的风险分别增加了 6%和 11%。
我们的研究结果表明，性别、无子、生育一个孩子和多胎次对 HTN 有不同的影响。需要进一步的研究来证实我们的发现。
