Department of Dermatology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Tokyo, Japan.
Acta Derm Venereol. 2013 Mar 27;93(2):144-9. doi: 10.2340/00015555-1428.
Many patients with cutaneous T-cell lymphoma (CTCL) experience severe pruritus. This study evaluated serum levels of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) in patients with CTCL. Although serum NGF and BDNF levels in patients with CTCL were not significantly higher than in healthy controls, serum NGF levels in patients with Sézary syndrome were higher than in those with mycosis fungoides and in healthy controls. Enhanced NGF expression by keratinocytes and increased dermal nerve fibres were detected in lesional skin of subjects with Sézary syndrome. Correlations between pruritus in CTCL and serum levels of NGF, BDNF, chemokine (C-C motif) ligand 1 (CCL1), CCL17, CCL26, CCL27, lactate dehydrogenase (LDH), IgE, and soluble interleukin-2 receptor were analysed. Serum CCL1, CCL26, LDH, and IgE levels correlated with pruritus in patients with CTCL. NGF may be associated with increased dermal nerve fibres and pruritus in Sézary syndrome, and CCL1, CCL26, and IgE may be associated with pruritus in CTCL.
许多皮肤 T 细胞淋巴瘤 (CTCL) 患者都经历严重的瘙痒。本研究评估了 CTCL 患者的神经生长因子 (NGF) 和脑源性神经营养因子 (BDNF) 的血清水平。虽然 CTCL 患者的血清 NGF 和 BDNF 水平与健康对照组相比没有显著升高，但蕈样真菌病患者的血清 NGF 水平高于蕈样肉芽肿患者和健康对照组。在患有 Sézary 综合征的患者的皮损皮肤中，检测到角质形成细胞增强的 NGF 表达和真皮神经纤维增多。分析了 CTCL 瘙痒与血清 NGF、BDNF、趋化因子 (C-C 基序) 配体 1 (CCL1)、CCL17、CCL26、CCL27、乳酸脱氢酶 (LDH)、IgE 和可溶性白细胞介素 2 受体之间的相关性。CTCL 患者的血清 CCL1、CCL26、LDH 和 IgE 水平与瘙痒相关。NGF 可能与 Sézary 综合征中真皮神经纤维和瘙痒增加有关，而 CCL1、CCL26 和 IgE 可能与 CTCL 的瘙痒有关。
