Post-Graduate Medical Institute, University of Hull, Cottingham Road, Hull, HU6 7RX, UK.
Mol Imaging Biol. 2012 Dec;14(6):653-66. doi: 10.1007/s11307-012-0590-y.
Despite being developed over 30 years ago, 2-deoxy-2-[(18)F]fluoro-D-glucose remains the most frequently used radiotracer in PET oncology. In the last decade, interest in new and more specific radiotracers for imaging biological processes of oncologic interest has increased exponentially. This review summarizes the strategies underlying the development of those probes together with their validation and status of clinical translation; a brief summary of new radiochemistry strategies applicable to PET imaging is also included. The article finishes with a consideration of the challenges imaging scientists must overcome to bring about increased adoption of PET as a diagnostic or pharmacologic tool.
尽管 2-脱氧-2-[(18)F]氟代-D-葡萄糖在 30 多年前就已开发出来，但它仍然是肿瘤学 PET 中使用最频繁的放射性示踪剂。在过去的十年中，人们对用于成像肿瘤学相关生物学过程的新型和更特异的放射性示踪剂的兴趣呈指数级增长。本文综述了开发这些探针的策略及其验证和临床转化的现状；还包括了适用于 PET 成像的新放射性化学策略的简要总结。文章最后考虑了成像科学家必须克服的挑战，以增加 PET 作为诊断或药理工具的应用。
