Key Laboratory of Structure-Based Drug Design & Discovery, Shenyang Pharmaceutical University, Ministry of Education, Shenyang, PR China.
Planta Med. 2012 Oct;78(15):1661-6. doi: 10.1055/s-0032-1315260. Epub 2012 Sep 4.
Five new 3,4-seco-lanostane-type triterpenoids, seco-coccinic acids G-K (1-5), and a known compound, seco-coccinic F, were isolated from the roots of Kadsura coccinea (Lem.) A. C. Sm. Their structures were elucidated by spectroscopic methods, including 2D-NMR and HR-MS techniques. The cell growth inhibitory effects of these compounds were assayed in human leukemia HL-60 cells, and it was found that 1, 5, and 6 showed antiproliferative effects with GI₅₀ values of 28.4, 15.2, and 16.6 µM, respectively.
从红毛藤（Kadsura coccinea（Lem.）A. C. Sm.）的根部分离得到五个新的 3,4-裂环羊毛甾烷型三萜类化合物，即 secococcinic 酸 G-K（1-5）和一个已知化合物 secococcinic F。通过包括 2D-NMR 和 HR-MS 技术在内的光谱方法阐明了它们的结构。这些化合物对人白血病 HL-60 细胞的生长抑制作用进行了测定，发现 1、5 和 6 具有抗增殖作用，GI₅₀ 值分别为 28.4、15.2 和 16.6 μM。
