Department of Biology, University of Erlangen-Nuernberg, Staudtstr 5, Erlangen 91058, Germany.
J Clin Immunol. 2013 Jan;33 Suppl 1:S4-8. doi: 10.1007/s10875-012-9782-0. Epub 2012 Sep 5.
Antibodies of the IgG isotype have a variety of pro- and anti-inflammatory effector functions, making them attractive platforms for the development of novel therapeutic approaches. Animal model systems have been invaluable to the understanding of the underlying mechanisms of IgG activity. However, differences in the IgG subclasses and Fc receptors responsible for mediating IgG-dependent effector functions, even between such closely related species as humans and monkeys, make it difficult to predict the activity of human IgG in vivo. This review will focus on currently available animal model systems used to study human IgG activity and will propose novel model systems that might enable us to obtain a closer look at the molecular and cellular mechanisms underlying human IgG activity in vivo.
IgG 抗体具有多种促炎和抗炎效应功能，使其成为开发新型治疗方法的有吸引力的平台。动物模型系统对于理解 IgG 活性的潜在机制非常有价值。然而，即使在人类和猴子等密切相关的物种之间，负责介导 IgG 依赖性效应功能的 IgG 亚型和 Fc 受体也存在差异，这使得难以预测人类 IgG 在体内的活性。本综述将重点介绍目前用于研究人类 IgG 活性的可用动物模型系统，并提出新的模型系统，使我们能够更深入地了解人类 IgG 在体内活性的分子和细胞机制。
