Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea.
Acta Derm Venereol. 2013 Mar 27;93(2):156-60. doi: 10.2340/00015555-1443.
A systemic pro-inflammatory and pro-coagulating state occurs in subjects who have both chronic urticaria and metabolic syndrome. To investigate the prevalence and clinical impact of metabolic syndrome in Korean patients with chronic urticaria, a hospital-based cross-sectional study of 131 patients was performed. Metabolic syndrome was assessed by the criteria of the National Cholesterol Education Program's Adult Treatment Panel III. Urticaria disease activity was assessed by total urticaria activity score (range 0-15). Thirty-nine patients (29.8%) had metabolic syndrome compared to 17.8% in a matched control group (p=0.001). Patients with chronic urticaria and metabolic syndrome were older, had a higher mean urticaria activity score and serum levels of eosinophil cationic protein, tumour necrosis factor-α, and complements, and showed a higher rate of negative autologous serum skin tests compared with those with-out metabolic syndrome. Logistic regression analysis indicated that an urticaria activity score of ≥ 13 (p=0.025) and the presence of metabolic syndrome (p=0.036) were independent predictors of uncontrolled chronic urticaria. We conclude that patients with severe and uncontrolled chronic urticaria should be evaluated for metabolic syndrome in order to reduce cardiovascular risk and improve chronic urticaria outcomes.
患有慢性荨麻疹和代谢综合征的患者会出现全身性促炎和促凝状态。为了研究代谢综合征在韩国慢性荨麻疹患者中的流行情况及其临床影响，我们对 131 例患者进行了一项基于医院的横断面研究。代谢综合征的评估标准采用国家胆固醇教育计划成人治疗专家组 III 的标准。荨麻疹疾病活动度通过总荨麻疹活动评分（范围 0-15）进行评估。与匹配对照组（17.8%）相比，39 例（29.8%）患者患有代谢综合征（p=0.001）。患有慢性荨麻疹和代谢综合征的患者年龄较大，荨麻疹活动评分、血清嗜酸性粒细胞阳离子蛋白、肿瘤坏死因子-α 和补体水平较高，且自身血清皮肤试验阴性率较高。Logistic 回归分析表明，荨麻疹活动评分≥13（p=0.025）和存在代谢综合征（p=0.036）是慢性荨麻疹控制不佳的独立预测因素。我们得出结论，对于严重和控制不佳的慢性荨麻疹患者，应评估其是否存在代谢综合征，以降低心血管风险并改善慢性荨麻疹的预后。
