Long Alan
SCYNEXIS, Research Triangle Park, NC, USA.
Curr Protoc Pharmacol. 2012 Sep;Chapter 9:Unit9.16. doi: 10.1002/0471141755.ph0916s58.
The tool chest of techniques, methodologies, and equipment for conducting parallel chemistry is larger than ever before. Improvements in the laboratory and developments in computational chemistry have enabled compound library design at the desks of medicinal chemists. This unit includes a brief background in combinatorial/parallel synthesis chemistry, along with a discussion of evolving technologies for both solid- and solution-phase chemistry. In addition, there are discussions on designing compound libraries, acquisition/procurement of compounds and/or reagents, the chemistry and equipment used for chemical production, purification, sample handling, and data analysis.
用于进行平行化学的技术、方法和设备的工具箱比以往任何时候都更加丰富。实验室的改进和计算化学的发展使药物化学家能够在办公桌前进行化合物库设计。本单元包括组合/平行合成化学的简要背景，以及对固相和溶液相化学不断发展的技术的讨论。此外，还讨论了化合物库的设计、化合物和/或试剂的获取/采购、用于化学生产、纯化、样品处理和数据分析的化学方法和设备。
