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本文引用的文献

1
Risk factors for Pneumocystis jiroveci pneumonia (PcP) in renal transplant recipients.肾移植受者中卡氏肺孢子菌肺炎（PcP）的危险因素。
Nephrol Dial Transplant. 2011 Jun;26(6):2013-7. doi: 10.1093/ndt/gfq689. Epub 2010 Nov 11.
2
Pneumocystis pneumonia in solid organ transplant recipients.实体器官移植受者中的肺孢子菌肺炎
Am J Transplant. 2009 Dec;9 Suppl 4:S227-33. doi: 10.1111/j.1600-6143.2009.02914.x.
3
Guidelines for prevention and treatment of opportunistic infections in HIV-infected adults and adolescents: recommendations from CDC, the National Institutes of Health, and the HIV Medicine Association of the Infectious Diseases Society of America.《HIV 感染成人及青少年机会性感染的预防与治疗指南：美国疾病控制与预防中心、国立卫生研究院及美国传染病学会 HIV 医学协会的建议》
MMWR Recomm Rep. 2009 Apr 10;58(RR-4):1-207; quiz CE1-4.
4
Mycophenolate mofetil may protect against Pneumocystis carinii pneumonia in renal transplanted patients.霉酚酸酯可能对肾移植患者的卡氏肺孢子虫肺炎具有预防作用。
Rev Inst Med Trop Sao Paulo. 2005 May-Jun;47(3):143-5. doi: 10.1590/s0036-46652005000300005. Epub 2005 Jul 12.
5
Pneumocystis pneumonia.肺孢子菌肺炎
N Engl J Med. 2004 Jun 10;350(24):2487-98. doi: 10.1056/NEJMra032588.
6
Risk factors for Pneumocystis carinii pneumonia in kidney transplant recipients: a case-control study.肾移植受者卡氏肺孢子虫肺炎的危险因素：一项病例对照研究。
Transpl Infect Dis. 2003 Jun;5(2):84-93. doi: 10.1034/j.1399-3062.2003.00018.x.
7
Discontinuation of secondary prophylaxis for Pneumocystis carinii pneumonia in human immunodeficiency virus-infected patients: a randomized trial by the CIOP Study Group.人类免疫缺陷病毒感染患者卡氏肺孢子虫肺炎二级预防的停用：CIOP研究组的一项随机试验
Clin Infect Dis. 2003 Mar 1;36(5):645-51. doi: 10.1086/367659. Epub 2003 Feb 12.
8
Opportunistic infections in patients with and patients without Acquired Immunodeficiency Syndrome.患有和未患有获得性免疫缺陷综合征患者的机会性感染。
Clin Infect Dis. 2002 Apr 15;34(8):1098-107. doi: 10.1086/339548. Epub 2002 Mar 21.
9
A randomized trial of the discontinuation of primary and secondary prophylaxis against Pneumocystis carinii pneumonia after highly active antiretroviral therapy in patients with HIV infection. Grupo de Estudio del SIDA 04/98.一项关于HIV感染患者接受高效抗逆转录病毒治疗后停止卡氏肺孢子虫肺炎一级和二级预防的随机试验。艾滋病研究小组04/98。
N Engl J Med. 2001 Jan 18;344(3):159-67. doi: 10.1056/NEJM200101183440301.
10
Epidemiology of human immunodeficiency virus-associated opportunistic infections in the United States in the era of highly active antiretroviral therapy.高效抗逆转录病毒治疗时代美国人类免疫缺陷病毒相关机会性感染的流行病学
Clin Infect Dis. 2000 Apr;30 Suppl 1:S5-14. doi: 10.1086/313843.

无论是否进行二级预防，实体器官移植后均无肺孢子菌肺炎复发。

No recurrence of Pneumocystis jirovecii Pneumonia after solid organ transplantation regardless of secondary prophylaxis.

机构信息

Departments of Infectious Diseases, University of Ulsan College of Medicine, Seoul, Republic of Korea.

出版信息

Antimicrob Agents Chemother. 2012 Nov;56(11):6041-3. doi: 10.1128/AAC.00998-12. Epub 2012 Sep 4.

DOI:10.1128/AAC.00998-12
PMID:22948875
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3486611/
Abstract

There are no data on the efficacy of secondary prophylaxis against Pneumocystis pneumonia after solid organ transplantation. Therefore, we investigated the rate of recurrence of Pneumocystis pneumonia after solid organ transplantation in a retrospective cohort study. Between 2005 and 2011, a total of 41 recipients recovered from Pneumocystis pneumonia. Of these, 22 (53.7%) received secondary prophylaxis. None of the 41 recipients experienced recurrence of Pneumocystis pneumonia during the follow-up, regardless of secondary prophylaxis.

摘要

尚无关于实体器官移植后预防卡氏肺孢子虫肺炎（PCP）复发的疗效数据。因此，我们通过回顾性队列研究调查了实体器官移植后 PCP 复发的发生率。2005 年至 2011 年期间，共有 41 例 PCP 痊愈的受者。其中，22 例（53.7%）接受了二级预防。41 例受者在随访期间均未发生 PCP 复发，无论是否接受二级预防。