Faculty of Pharmacy, The University of Sydney, Sydney, Australia.
Clin Pharmacol Ther. 2012 Oct;92(4):511-9. doi: 10.1038/clpt.2012.139. Epub 2012 Sep 5.
The drug-metabolizing enzyme CYP1A2 contributes to the metabolism of a number of commonly used medicines and displays wide interindividual variability. The aim of this study was to investigate CYP1A2 activity in a population of South Asian ancestry and compare it with a population of European ancestry. CYP1A2 activity was determined using the 4 h paraxanthine/caffeine saliva concentration ratio following a 100-mg oral dose of caffeine in healthy individuals of South Asian (n = 166) and European (n = 166) ancestry. Participants were surveyed for extrinsic ethnic factors and genotyped for polymorphisms in CYP1A2 and related genes. Significantly lower CYP1A2 activity was observed in South Asian participants (median: 0.42; range: 0.10-1.06) as compared with European participants (0.54; 0.12-1.64) (P < 0.01). Multiple linear regression indicated that 41% of the variability in CYP1A2 activity could be explained by the diet, lifestyle, and genetic factors studied.
药物代谢酶 CYP1A2 参与了许多常用药物的代谢，并且表现出广泛的个体间变异性。本研究旨在调查南亚人群中的 CYP1A2 活性，并将其与欧洲人群进行比较。在健康的南亚（n=166）和欧洲（n=166）人群中，通过口服 100mg 咖啡因后 4 小时的副黄嘌呤/咖啡因唾液浓度比来测定 CYP1A2 活性。调查了参与者的外在种族因素，并对 CYP1A2 和相关基因的多态性进行了基因分型。与欧洲参与者（0.54；0.12-1.64）相比，南亚参与者的 CYP1A2 活性明显较低（中位数：0.42；范围：0.10-1.06）（P<0.01）。多元线性回归表明，通过研究的饮食、生活方式和遗传因素，可以解释 CYP1A2 活性变异性的 41%。
