Clouston P D, Sharpe D M, Corbett A J, Kos S, Kennedy P J
Department of Neurology, Repatriation General Hospital, Concord, Sydney, Australia.
Arch Neurol. 1990 Jan;47(1):73-7. doi: 10.1001/archneur.1990.00530010091025.
The ability of cutaneous squamous cell carcinoma of the face to cause ophthalmoplegia or central nervous system dysfunction via perineural spread is not well recognized. Five patients presenting to a general neurology unit are described in whom partial or complete ophthalmoplegia developed following fifth and seventh cranial nerve involvement by cutaneous squamous cell carcinoma. Two patients subsequently developed a contralateral hemiparesis; and one, multiple cranial nerve palsies as the tumor spread centrally. Normal radiologic findings or complete healing of the primary skin lesion caused delay in the diagnosis in three of the patients. When ophthalmoplegia or central nervous system dysfunction develops as a consequence of perineural spread of cutaneous facial cancer, management is palliative.
面部皮肤鳞状细胞癌通过神经周围扩散导致眼肌麻痹或中枢神经系统功能障碍的能力尚未得到充分认识。本文描述了五例就诊于普通神经科的患者，他们因面部皮肤鳞状细胞癌累及第五和第七颅神经后出现了部分或完全性眼肌麻痹。两名患者随后出现对侧偏瘫；一名患者因肿瘤向中枢扩散而出现多发性颅神经麻痹。三名患者因影像学检查结果正常或原发性皮肤病变完全愈合而导致诊断延迟。当眼肌麻痹或中枢神经系统功能障碍因面部皮肤癌的神经周围扩散而发生时，治疗是姑息性的。
