State Key Laboratory of Natural and Biomimetic Drugs, Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, PR China.
Org Biomol Chem. 2012 Oct 21;10(39):7869-71. doi: 10.1039/c2ob26430g.
We have developed a new KI-catalyzed method for the imidation of an sp(3) C-H bond adjacent to an amide nitrogen atom by using TBHP (tert-butyl hydroperoxide, 70% aqueous solution) as the oxidant. This novel procedure tolerated air and moisture and provided a series of novel products in moderate to excellent yields under mild conditions.
我们开发了一种新的 KI 催化方法，通过使用 TBHP（叔丁基过氧化氢，70%水溶液）作为氧化剂，实现了酰胺氮原子邻位 sp(3) C-H 键的亚胺化。该新方法耐受空气和水分，在温和条件下以中等至优异的收率提供了一系列新型产物。
