选择性 C(sp2)-C(sp)键断裂：炔烃的氮化成酰胺。
Selective C(sp2)-C(sp) bond cleavage: the nitrogenation of alkynes to amides.
机构信息
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Rd. 38, Beijing 100191, China.
出版信息
Angew Chem Int Ed Engl. 2013 Jul 22;52(30):7850-4. doi: 10.1002/anie.201303376. Epub 2013 Jun 26.
PMID:23804537
Abstract
Breakthrough: A novel catalyzed direct highly selective C(sp2)-C(sp) bond functionalization of alkynes to amides has been developed. Nitrogenation is achieved by the highly selective C(sp2)-C(sp) bond cleavage of aryl-substituted alkynes. The oxidant-free and mild conditions and wide substrate scope make this method very practical.
摘要
突破
开发了一种新型催化的炔烃到酰胺的直接高选择性 C(sp2)-C(sp)键官能化方法。氮化为芳基取代的炔烃的高选择性 C(sp2)-C(sp)键断裂来实现。无氧化剂且温和的条件以及广泛的底物范围使得该方法非常实用。
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