持续抗原导致的 T 细胞耗竭：数量而非质量？
T-cell exhaustion due to persistent antigen: quantity not quality?
机构信息
Division of Biological Sciences, University of California San Diego, La Jolla, San Diego, CA, USA.
出版信息
Eur J Immunol. 2012 Sep;42(9):2285-9. doi: 10.1002/eji.201242852.
Abstract
T-cell exhaustion is characterized by failure to respond to a persistent antigen and is a hallmark of chronic infections and cancer. Here, we discuss several recent reports on T-cell exhaustion, including one in this issue of the European Journal of Immunology where Richter et al. [Eur. J. Immunol. 42:2290-2304] examine the importance of the amount of persistent antigen versus the cell type presenting it to induce CD8(+) T-cell exhaustion, and the consequences for host survival during chronic viral infection.
摘要
T 细胞耗竭的特征是对持续性抗原的反应失败，这是慢性感染和癌症的标志。在这里，我们讨论了几项关于 T 细胞耗竭的最新报告，包括本期《欧洲免疫学杂志》中的一篇文章，其中 Richter 等人[Eur. J. Immunol. 42:2290-2304]研究了持续性抗原的量与呈递抗原的细胞类型之间的关系，以及它们在慢性病毒感染期间对宿主存活的影响。
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本文引用的文献
1
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2
Timing and magnitude of type I interferon responses by distinct sensors impact CD8 T cell exhaustion and chronic viral infection.
Cell Host Microbe. 2012 Jun 14;11(6):631-42. doi: 10.1016/j.chom.2012.05.003.
3
Plasmacytoid dendritic cells are productively infected and activated through TLR-7 early after arenavirus infection.
Cell Host Microbe. 2012 Jun 14;11(6):617-30. doi: 10.1016/j.chom.2012.04.017.
4
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5
Emergence of distinct multiarmed immunoregulatory antigen-presenting cells during persistent viral infection.
Cell Host Microbe. 2012 May 17;11(5):481-91. doi: 10.1016/j.chom.2012.03.009.
6
Natural killer cells act as rheostats modulating antiviral T cells.
Nature. 2011 Nov 20;481(7381):394-8. doi: 10.1038/nature10624.
7
Late interleukin-6 escalates T follicular helper cell responses and controls a chronic viral infection.
Science. 2011 Nov 11;334(6057):825-9. doi: 10.1126/science.1208421. Epub 2011 Sep 29.
8
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Nat Immunol. 2011 Jun;12(6):492-9. doi: 10.1038/ni.2035.
9
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10
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Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2969-74. doi: 10.1073/pnas.1019304108. Epub 2011 Jan 26.
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