Division of Biological Sciences, University of California San Diego, La Jolla, San Diego, CA, USA.
Eur J Immunol. 2012 Sep;42(9):2285-9. doi: 10.1002/eji.201242852.
T-cell exhaustion is characterized by failure to respond to a persistent antigen and is a hallmark of chronic infections and cancer. Here, we discuss several recent reports on T-cell exhaustion, including one in this issue of the European Journal of Immunology where Richter et al. [Eur. J. Immunol. 42:2290-2304] examine the importance of the amount of persistent antigen versus the cell type presenting it to induce CD8(+) T-cell exhaustion, and the consequences for host survival during chronic viral infection.
T 细胞耗竭的特征是对持续性抗原的反应失败，这是慢性感染和癌症的标志。在这里，我们讨论了几项关于 T 细胞耗竭的最新报告，包括本期《欧洲免疫学杂志》中的一篇文章，其中 Richter 等人[Eur. J. Immunol. 42:2290-2304]研究了持续性抗原的量与呈递抗原的细胞类型之间的关系，以及它们在慢性病毒感染期间对宿主存活的影响。
