Manschreck T C, Keuthen N J, Schneyer M L, Celada M T, Laughery J, Collins P
Massachusetts General Hospital, Harvard Medical School, Boston 02114.
Biol Psychiatry. 1990 Jan 15;27(2):150-8. doi: 10.1016/0006-3223(90)90645-i.
We hypothesized that chronic schizophrenic patients with abnormal involuntary movements would exhibit specific psychopathological, neurological, and cognitive disturbances at a more severe level than those free of such movements. Twenty-two chronic schizophrenic patients were assessed for abnormal movements, cognitive impairment, psychopathology, and medication history. Unequivocal evidence of movement abnormality on the Abnormal Involuntary Movement Scale divided the subjects into groups with (n = 13) and without (n = 9) involuntary movement anomaly. Age, education, length of illness, depressive symptoms, total symptom ratings, and medication variables did not differ in the two groups. However, the group with involuntary movements had more negative symptomatology, greater impairment on voluntary motor tasks, lower premorbid intelligence, and a trend toward poorer recall on mental status examination. These results demonstrate that schizophrenic patients with abnormal involuntary movements have more severe psychopathology as reflected in certain defect symptoms, more abnormal voluntary movements, and more cognitive impairment than schizophrenic patients without involuntary movements.
我们假设，患有异常不自主运动的慢性精神分裂症患者会比没有此类运动的患者表现出更严重的特定精神病理学、神经学和认知障碍。对22名慢性精神分裂症患者进行了异常运动、认知障碍、精神病理学和用药史评估。异常不自主运动量表上明确的运动异常证据将受试者分为有（n = 13）和无（n = 9）不自主运动异常的两组。两组在年龄、教育程度、病程、抑郁症状、总症状评分和用药变量方面没有差异。然而，有不自主运动的组有更多的阴性症状，在自愿运动任务上有更大的损伤，病前智力较低，并且在精神状态检查中回忆能力有较差的趋势。这些结果表明，与没有不自主运动的精神分裂症患者相比，有异常不自主运动的精神分裂症患者在某些缺陷症状方面表现出更严重的精神病理学，有更多的异常自主运动和更多的认知障碍。
