生长抑素-28 和寡肽生长抑素激动剂通过与不同的生长抑素受体亚型相互作用，对防止应激引起的内分泌、自主和内脏反应的成分产生中枢作用。
Central actions of somatostatin-28 and oligosomatostatin agonists to prevent components of the endocrine, autonomic and visceral responses to stress through interaction with different somatostatin receptor subtypes.
机构信息
CURE: Digestive Diseases Research Center and Center for Neurovisceral Sciences & Women's Health, Digestive Diseases Division, David Geffen School of Medicine at UCLA and VA Greater Los Angeles Healthcare System, Los Angeles, California, USA.
出版信息
Curr Pharm Des. 2013;19(1):98-105. doi: 10.2174/13816128130114.
Abstract
Somatostatin was discovered four decades ago and since then its physiological role has been extensively investigated, first in relation with its inhibitory effect on growth hormone secretion but soon it expanded to extrapituitary actions influencing various stressresponsive systems. Somatostatin is expressed in distinct brain nuclei and binds to five somatostatin receptor subtypes which are also widely expressed in the brain with a distinct distribution pattern. The last few years witnessed the discovery of highly selective peptide somatostatin receptor agonists and antagonists representing valuable tools to delineate the respective pathways of somatostatin signaling. Here we review the centrally mediated actions of somatostatin and related selective somatostatin receptor subtype agonists to influence the endocrine, autonomic, and visceral components of the stress response and basal behavior as well as thermogenesis.
摘要
生长抑素在四十年前被发现，自此其生理作用得到了广泛研究，最初是其对生长激素分泌的抑制作用，但很快就扩展到了影响各种应激反应系统的腺外作用。生长抑素在不同的脑核中表达，并与五种生长抑素受体亚型结合，这些受体亚型也广泛表达于脑内，具有独特的分布模式。在过去的几年中，人们发现了高度选择性的肽生长抑素受体激动剂和拮抗剂，这些激动剂和拮抗剂是描绘生长抑素信号转导的相关途径的有价值的工具。在这里，我们综述了生长抑素及其相关的选择性生长抑素受体亚型激动剂的中枢介导作用，以影响应激反应和基础行为的内分泌、自主和内脏成分以及生热作用。
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