紫杉醇注射液中乙醇对呼气中乙醇浓度的影响。

Effect of ethanol in Paclitaxel injections on the ethanol concentration in exhaled breath.

机构信息

Center for Medical Education, Gunma University Graduate School of Medicine, Maebashi, Japan.

出版信息

Drugs R D. 2012 Sep 1;12(3):165-70. doi: 10.2165/11634690-000000000-00000.

DOI:10.2165/11634690-000000000-00000

PMID:22950523

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3585845/

Abstract

BACKGROUND

Ethanol is included in certain injectable preparations of anticancer drugs to increase their solubility. Since the volume of ethanol in these preparations is approximately half of the total injection volume, the potential inhibitory effects of ethanol on the central nervous system cannot be disregarded, especially considering that patients may drive immediately after administration of the medication. Therefore, the concentration of ethanol was examined in exhaled breath after administration of paclitaxel, an anticancer medication containing ethanol.

METHODS

The ethanol concentration in exhaled breath immediately after an intravenous infusion of paclitaxel was measured in 30 patients, using a balloon-type gas detector tube. Correlations between the concentration of ethanol in exhaled breath and the total amount of ethanol administered or the intravenous infusion speed were calculated.

RESULTS

The mean ethanol concentration in exhaled breath was 0.028 ± 0.015 mg/L. The correlation between the ethanol concentration in exhaled breath and the total dose of ethanol was weak (R2 = 0.25; p = 0.055), while the intravenous infusion speed showed a stronger positive correlation with the concentration of ethanol in the breath (R2 = 0.49; p = 0.11). The maximum concentration of ethanol measured in exhaled breath (0.06 mg/L) was equivalent to 40% of the threshold for drunk driving, as specified in the Road Traffic Act in Japan.

CONCLUSION

In this study, no patient had a breath ethanol concentration exceeding the legal threshold for drunk driving. However, it is still advisable for patients to avoid driving after receiving paclitaxel injections. When driving cannot be avoided, patients should wait for a sufficient time after receiving the injection before driving.

摘要

背景

某些抗癌药物的注射制剂中含有乙醇，以增加其溶解度。由于这些制剂中乙醇的体积约占总注射体积的一半，因此不能忽视乙醇对中枢神经系统的潜在抑制作用，尤其是考虑到患者在给药后可能会立即开车。因此，研究检测了含有乙醇的抗癌药物紫杉醇给药后呼气中的乙醇浓度。

方法

通过气囊式气体检测管测量 30 例患者静脉输注紫杉醇后呼气中乙醇的浓度。计算呼气中乙醇浓度与给予的乙醇总量或静脉输注速度之间的相关性。

结果

呼气中乙醇的平均浓度为 0.028 ± 0.015 mg/L。呼气中乙醇浓度与乙醇总剂量之间的相关性较弱（R2=0.25；p=0.055），而静脉输注速度与呼气中乙醇浓度呈更强的正相关（R2=0.49；p=0.11）。呼气中测得的乙醇最高浓度（0.06mg/L）相当于日本《道路交通法》规定的酒后驾车阈值的 40%。