Yousem S A, Colby T V
Department of Pathology, Presbyterian University Hospital University of Pittsburgh School of Medicine, Pennsylvania 15213.
Cancer. 1990 Jan 15;65(2):349-53. doi: 10.1002/1097-0142(19900115)65:2<349::aid-cncr2820650228>3.0.co;2-c.
We report four patients who had intravascular lymphomatosis (IVL) that presented as interstitial lung disease. All four patients had progressive shortness of breath, weight loss, fever, and diffuse interstitial infiltrates on chest radiographs. Open lung biopsy samples showed an interstitial pneumonia except for the intravascular proliferation of large lymphoid cells associated with irregular congestion, fibrin microthrombi, and intimal proliferation in vessels. This appearance corresponded to an intravascular large cell lymphoma (malignant angioendotheliomatosis [MAE], angiotropic lymphoma). The differential diagnosis of IVL with other pulmonary lymphoproliferations and intravascular malignancies is reported.
我们报告了4例表现为间质性肺病的血管内淋巴瘤（IVL）患者。所有4例患者均有进行性气短、体重减轻、发热，胸部X线片显示弥漫性间质浸润。开胸肺活检样本显示为间质性肺炎，除了大淋巴细胞的血管内增殖，伴有不规则充血、纤维蛋白微血栓形成以及血管内膜增殖。这种表现符合血管内大细胞淋巴瘤（恶性血管内皮瘤病[MAE]，亲血管性淋巴瘤）。本文报道了IVL与其他肺部淋巴增殖性疾病及血管内恶性肿瘤的鉴别诊断。
