Khojeini Elham Vali, Song Joo Young
Department of Pathology and Laboratory Medicine, University of California, Davis, 4400 V Street, Sacramento, CA 95817, USA.
Department of Pathology, City of Hope, 1500 E Duarte Road, Duarte, CA 91010, USA.
Case Rep Pathol. 2014;2014:928065. doi: 10.1155/2014/928065. Epub 2014 May 15.
Intravascular large B-cell lymphoma (IVLBL) is a rare subtype of diffuse large B-cell lymphoma that resides in the lumen of blood vessels. Patients typically present with nonspecific findings, particularly bizarre neurologic symptoms, fever, and skin lesions. A woman presented with shortness of breath and a chest CT scan showed diffuse interstitial thickening and ground glass opacities suggestive of an interstitial lung disease. On physical exam she was noted to have splenomegaly. The patient died and at autopsy was found to have an IVLBL in her lungs as well as nearly all her organs that were sampled. Although rare, IVLBL should be included in the differential diagnosis of interstitial lung disease and this case underscores the importance of the continuation of autopsies.
血管内大B细胞淋巴瘤（IVLBL）是弥漫性大B细胞淋巴瘤的一种罕见亚型，位于血管腔内。患者通常表现为非特异性症状，尤其是怪异的神经系统症状、发热和皮肤病变。一名女性出现呼吸急促，胸部CT扫描显示弥漫性间质增厚和磨玻璃影，提示间质性肺疾病。体格检查发现她有脾肿大。患者死亡，尸检发现其肺部以及几乎所有取样的器官都存在IVLBL。尽管罕见，但IVLBL应纳入间质性肺疾病的鉴别诊断，该病例强调了继续进行尸检的重要性。
