微生物代谢。第 14 部分。白藜芦醇微生物代谢产物的分离与生物活性评价。
Microbial metabolism. Part 14. Isolation and bioactivity evaluation of microbial metabolites of resveratrol.
机构信息
a National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi , University , MS 38677 , USA.
出版信息
Nat Prod Res. 2013;27(16):1437-44. doi: 10.1080/14786419.2012.722089. Epub 2012 Sep 6.
The fungi, Beauveria bassiana (ATCC 13144) and Penicillium chrysogenium (ATCC 9480) transformed resveratrol to resveratrol-3-O-sulphate. The former, in addition, gave 5-methoxyresveratrol-3-O-β-glucoside with the latter yielding 5-methoxyresveratrol-3-O-sulphate. The structures were established by spectroscopic methods. Evaluation of biological activity of metabolites through a series of mammalian cell based assays indicated that resveratrol tends to lose its anti-inflammatory, cytotoxic and anti-oxidant activities with the substitution of its hydroxyl groups.
真菌，淡紫拟青霉（ATCC 13144）和产黄青霉（ATCC 9480）将白藜芦醇转化为白藜芦醇-3-O-硫酸盐。前者还生成 5-甲氧基白藜芦醇-3-O-β-葡萄糖苷，后者生成 5-甲氧基白藜芦醇-3-O-硫酸盐。结构通过光谱方法确定。通过一系列基于哺乳动物细胞的测定评估代谢物的生物活性表明，白藜芦醇的羟基被取代后，其抗炎、细胞毒性和抗氧化活性往往会丧失。
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