Department of Molecular Science and Technology, Ajou University, Suwon 16499, Korea.
S&K Therapeutics, Ajou University Campus Plaza 418, 199 Worldcup-ro, Yeongtong-gu, Suwon 16502, Korea.
Cells. 2022 Apr 13;11(8):1326. doi: 10.3390/cells11081326.
Despite significant technological advancements in conventional therapies, cancer remains one of the main causes of death worldwide. Although substantial progress has been made in the control and treatment of cancer, several limitations still exist, and there is scope for further advancements. Several adverse effects are associated with modern chemotherapy that hinder cancer treatment and lead to other critical disorders. Since ancient times, plant-based medicines have been employed in clinical practice and have yielded good results with few side effects. The modern research system and advanced screening techniques for plants' bioactive constituents have enabled phytochemical discovery for the prevention and treatment of challenging diseases such as cancer. Phytochemicals such as vincristine, vinblastine, paclitaxel, curcumin, colchicine, and lycopene have shown promising anticancer effects. Discovery of more plant-derived bioactive compounds should be encouraged via the exploitation of advanced and innovative research techniques, to prevent and treat advanced-stage cancers without causing significant adverse effects. This review highlights numerous plant-derived bioactive molecules that have shown potential as anticancer agents and their probable mechanisms of action and provides an overview of in vitro, in vivo and clinical trial studies on anticancer phytochemicals.
尽管传统疗法在技术上取得了重大进展，但癌症仍然是全球主要死亡原因之一。尽管在癌症的控制和治疗方面已经取得了重大进展，但仍存在一些局限性，还有进一步发展的空间。现代化疗存在一些副作用，这些副作用会阻碍癌症的治疗，并导致其他严重的疾病。自古以来，植物药就在临床实践中得到应用，并且具有良好的疗效和很少的副作用。现代研究系统和先进的植物生物活性成分筛选技术使植物化学物质的发现得以用于预防和治疗癌症等具有挑战性的疾病。长春新碱、长春碱、紫杉醇、姜黄素、秋水仙碱和番茄红素等植物化学物质已显示出有希望的抗癌作用。应该鼓励通过利用先进和创新的研究技术来发现更多的植物源性生物活性化合物，以预防和治疗晚期癌症而不会产生显著的副作用。这篇综述强调了许多具有抗癌潜力的植物源性生物活性分子及其可能的作用机制，并概述了抗癌植物化学物质的体外、体内和临床试验研究。
