Wiesel S, Fox G S
Department of Anaesthesia, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, Quebec.
Can J Anaesth. 1990 Jan;37(1):122-6. doi: 10.1007/BF03007492.
The perioperative anaesthetic management of an adult patient with central alveolar hypoventilation syndrome (CAHS), Ondine's Curse, is described for anterior resection of a carcinoma of the bowel. This rare syndrome results in alveolar hypoventilation, hypercarbia, hypoxaemia with secondary polycythaemia, pulmonary artery hypertension, and cor pulmonale. Epidural morphine was used for postoperative analgesia in an attempt to improve postoperative respiratory function. However, postoperative mechanical ventilation was required until recovery of the respiratory drive, which was ablated by anaesthetic drugs, epidural morphine and high inspired oxygen concentrations. The pathophysiology and treatment of this syndrome are reviewed.
本文描述了一名患有中枢性肺泡低通气综合征（CAHS）即翁丁氏诅咒的成年患者在接受肠道癌前切除术时的围手术期麻醉管理。这种罕见综合征会导致肺泡低通气、高碳酸血症、低氧血症伴继发性红细胞增多症、肺动脉高压和肺心病。使用硬膜外吗啡进行术后镇痛，试图改善术后呼吸功能。然而，术后需要机械通气直至呼吸驱动力恢复，呼吸驱动力因麻醉药物、硬膜外吗啡和高吸入氧浓度而受到抑制。本文还对该综合征的病理生理学和治疗方法进行了综述。
