Svistunov A A, Mareev O V, Mareev G O, Bukreev I S
Vestn Otorinolaringol. 2012(3):34-8.
to investigate the influence of various intranasal medications on the microcirculatory bed in nasal cavity mucosa using the original method of laser Doppler flowmetry.
this comprehensive study of the influence of intranasal medicines on nasal cavity mucosa using laser Doppler flowmetry was designed to evaluate the mucociliary clearance, breathing efficiency of the nose, and subjective symptoms of its impairment. The outcomes of a single application of intranasal medications were estimated in 90 rhinologically healthy subjects; in 15 of them, the micrcirculatory blood flow in the nasal cavity was investigated in the early postoperative period with the use of intranasal decongestants and irrigation products.
this study has demonstrated the relationship between the changes in the microcirculatory bed and the application of intranasal medications acting on nasal mucosa. Moreover, these agents were shown to affect intranasal mucosa and its microcirculatory bed following rhinological surgical interventions. Tachyphylaxis of the microcirculatory bed after the administration of the decongestants developed earlier than previously thought. At the came time, irrigation therapy exerted the beneficial effect on the state of the intranasal microcirculatory bed in the postoperative period.
采用激光多普勒血流仪的原始方法，研究各种鼻内用药对鼻腔黏膜微循环床的影响。
本研究采用激光多普勒血流仪全面研究鼻内用药对鼻腔黏膜的影响，旨在评估黏液纤毛清除功能、鼻腔呼吸效率及其受损的主观症状。对90名鼻科健康受试者单次使用鼻内用药的效果进行了评估；其中15名受试者在术后早期使用鼻内减充血剂和冲洗产品，对鼻腔内的微循环血流进行了研究。
本研究证实了微循环床的变化与作用于鼻黏膜的鼻内用药之间的关系。此外，这些药物在鼻科手术干预后对鼻内黏膜及其微循环床有影响。减充血剂给药后微循环床的快速耐受性比之前认为的出现得更早。与此同时，冲洗疗法在术后对鼻内微循环床的状态产生了有益影响。
