滴鼻剂可引起兔鼻窦黏膜微循环中的血管运动。

Nose drops induce vasomotion in the microcirculation of the sinus mucosa of the rabbit.

作者信息

Bende M, Arfors K E, Intaglietta M

机构信息

Department of Applied Mechanics, University of California, San Diego, La Jolla.

出版信息

ORL J Otorhinolaryngol Relat Spec. 1993 Mar-Apr;55(2):110-3. doi: 10.1159/000276392.

DOI:10.1159/000276392

PMID:7680443

Abstract

Periodic oscillations of blood in the microcirculation of the sinus mucosa in the rabbit were studied with laser-Doppler flowmetry after the application of nose drops (oxymetazoline, xylometazoline and phenylephrine) to the nasal mucosa. All of these drugs induced a dose-dependent decrease in the blood flow in the mucosa. Flowmotion was found in 9 of 21 experiments after an approximately 50% reduction in blood flow had been induced. The concentrations of the drugs which caused vasomotion corresponded to those normally administered as nose drops to man.

摘要

在给兔鼻黏膜滴用滴鼻剂（羟甲唑啉、赛洛唑啉和去氧肾上腺素）后，使用激光多普勒血流仪研究了兔鼻窦黏膜微循环中血液的周期性振荡。所有这些药物均导致黏膜血流呈剂量依赖性减少。在诱导血流减少约50%后的21次实验中，有9次发现了血流运动。引起血管运动的药物浓度与通常给人使用的滴鼻剂浓度相当。