IFOM Foundation-FIRC Institute of Molecular Oncology Foundation, Milan 20139, Italy.
Nat Rev Cancer. 2012 Oct;12(10):709-20. doi: 10.1038/nrc3344. Epub 2012 Sep 6.
The generation of DNA lesions and the resulting activation of DNA damage response (DDR) pathways are both affected by the chromatin status at the site of damaged DNA. In turn, DDR activation affects the chromatin at both the damaged site and across the whole genome. Cellular senescence and cancer are associated with the engagement of the DDR pathways and with profound chromatin changes. In this Opinion article, we discuss the interplay between chromatin and DDR factors in the context of cellular senescence that is induced by oncogenes and in cancer.
DNA 损伤的产生以及由此导致的 DNA 损伤反应 (DDR) 途径的激活都受到损伤 DNA 部位染色质状态的影响。反过来，DDR 的激活又会影响损伤部位和整个基因组的染色质。细胞衰老和癌症与 DDR 途径的激活以及深刻的染色质变化有关。在这篇观点文章中，我们讨论了染色质与 DDR 因子在致癌基因诱导的细胞衰老和癌症中的相互作用。
