MOE key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, PR China.
Chem Commun (Camb). 2012 Oct 18;48(81):10126-8. doi: 10.1039/c2cc34768g.
PEG-detachable polyplexes were constructed for the first time via host-guest interactions between β-cyclodextrin and azobenzene. The polyplexes had excellent colloidal stability and competition stability. Moreover, the intracellular light-regulated dePEGylation facilitated DNA release and nuclear entry, thus resulting in efficient transfection.
首次通过β-环糊精和偶氮苯之间的主客体相互作用构建了可 PEG 去除的超分子聚合物。该超分子聚合物具有优异的胶体稳定性和竞争稳定性。此外，细胞内光调控的去 PEG 化促进了 DNA 的释放和核内进入，从而实现了高效转染。
