用于细胞内药物递送的双响应超分子纳米凝胶
Dual responsive supramolecular nanogels for intracellular drug delivery.
作者信息
Chen Xiaofei, Chen Li, Yao Xuemei, Zhang Zhe, He Chaoliang, Zhang Jingping, Chen Xuesi
机构信息
Department of Chemistry, Northeast Normal University, Changchun 130024, P. R. China.
出版信息
Chem Commun (Camb). 2014 Apr 14;50(29):3789-91. doi: 10.1039/c4cc00016a. Epub 2014 Feb 12.
Supramolecular nanogels cross-linked by host-guest interaction between dextran grafted benzimidazole (Dex-g-BM) and thiol-β-cyclodextrin were designed. Their special supramolecular pH-sensitivity under acidic conditions (pH < 6, within the range of malignant cellular endosomes) and reduction sensitivity in response to biologically relevant stimuli will be of great advantage to the future of cancer chemotherapeutics.
设计了通过葡聚糖接枝苯并咪唑（Dex-g-BM）与硫醇-β-环糊精之间的主客体相互作用交联的超分子纳米凝胶。它们在酸性条件下（pH < 6，在恶性细胞内体范围内）具有特殊的超分子pH敏感性，并且对生物相关刺激具有还原敏感性，这将对未来的癌症化疗具有很大优势。
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