Boggon Rachael, Timmis Adam, Hemingway Harry, Raju Sunil, Malvestiti Franco Mondello, Van Staa Tjeerd P
General Practice Research Database, MHRA, London, UK.
Barts and the London School of Medicine and Dentistry, London, UK.
Eur J Prev Cardiol. 2014 Jun;21(6):767-73. doi: 10.1177/2047487312460517. Epub 2012 Sep 5.
It is recommended that general practitioners (GPs) offer cessation advice and pharmacological interventions to smokers with acute coronary syndrome (ACS). The study objective was to describe the extent to which this is done, and to describe outcomes by smoking status.
Patients aged 30+ hospitalised for troponin-positive ACS from 2002 to 2009, discharged home alive, were identified in the Myocardial Ischaemia National Audit Project registry. Patient data were linked to the General Practice Research Database, Hospital Episode Statistics, and Office of National Statistics mortality data, enabling a unique perspective of longitudinal smoking data. Patients who smoked prior to the hospitalisation had GP interventions and quitting status established in the 3 months following discharge, and were followed up for major clinical outcomes.
The outcomes evaluated included death, repeat ACS, stroke, heart failure, and major adverse cardiac events (MACE).
Of the 4834 patients included, 965 (20%) were smokers at the time of their ACS. After the ACS event, only 225 (24%) received any GP smoking intervention within 3 months, with 82 (9%) receiving advice only, and 143 (15%) receiving a pharmacological intervention. Patients who quit (320; 33%) were at a decreased risk of mortality (relative risk (RR) 0.49; 95% confidence interval (CI) 0.35-0.69) and MACE (RR 0.61; 0.46-0.80) compared with patients who did not.
Whilst a high proportion of patients with ACS are smokers, there is a low level of GP cessation intervention following hospital discharge. This missed opportunity of patient care is important given the decreased risk of mortality and MACE found amongst those who quit.
建议全科医生(GP)为急性冠状动脉综合征(ACS)患者提供戒烟建议和药物干预。本研究的目的是描述这一建议的实施程度,并按吸烟状况描述结果。
在心肌缺血国家审计项目登记处中识别出2002年至2009年因肌钙蛋白阳性ACS住院、30岁及以上且存活出院回家的患者。患者数据与全科医疗研究数据库、医院事件统计数据以及国家统计局死亡率数据相关联,从而能够从独特视角获取纵向吸烟数据。住院前吸烟的患者在出院后3个月内接受了全科医生干预并确定了戒烟状态,并对主要临床结果进行随访。
评估的结果包括死亡、再次发生ACS、中风、心力衰竭和主要不良心脏事件(MACE)。
在纳入的4834例患者中,965例(20%)在发生ACS时为吸烟者。ACS事件后,仅225例(24%)在3个月内接受了任何全科医生的吸烟干预,其中82例(9%)仅接受了建议,143例(15%)接受了药物干预。与未戒烟的患者相比,戒烟的患者(320例;33%)死亡风险(相对风险(RR)0.49;95%置信区间(CI)0.35 - 0.69)和MACE风险(RR 0.61;0.46 - 0.80)降低。
虽然ACS患者中吸烟者比例较高,但出院后全科医生的戒烟干预水平较低。鉴于戒烟者的死亡风险和MACE风险降低,这种错过的患者护理机会很重要。