Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Cold Spring Harb Perspect Biol. 2012 Sep 1;4(9):a007021. doi: 10.1101/cshperspect.a007021.
Regulatory T cells expressing the FoxP3 transcription factor have a profound and nonredundant role in several aspects of immunological tolerance. We will review here the specification of this lineage, its population dynamics, and the diversity of subphenotypes that correlate with their diverse roles in controlling inflammation in a variety of settings.
表达转录因子 FoxP3 的调节性 T 细胞在免疫耐受的几个方面发挥着深远且不可或缺的作用。我们将在这里回顾该谱系的特异性、其群体动力学以及与其在各种环境中控制炎症的多种作用相关的多种亚表型的多样性。
