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1
PIKKing on PKB: regulation of PKB activity by phosphorylation.聚焦蛋白激酶 B：磷酸化对蛋白激酶 B 活性的调控
Curr Opin Cell Biol. 2009 Apr;21(2):256-61. doi: 10.1016/j.ceb.2009.02.002. Epub 2009 Mar 19.
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AKT/PKB signaling: navigating downstream.AKT/蛋白激酶B信号传导：下游通路解析
Cell. 2007 Jun 29;129(7):1261-74. doi: 10.1016/j.cell.2007.06.009.
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PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms.PHLPP及第二种同种型PHLPP2通过调节不同的Akt同种型来差异性地减弱Akt信号传导的幅度。
Mol Cell. 2007 Mar 23;25(6):917-31. doi: 10.1016/j.molcel.2007.02.017.
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Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40.由Akt/PKB底物PRAS40介导的胰岛素向mTOR的信号传导。
Nat Cell Biol. 2007 Mar;9(3):316-23. doi: 10.1038/ncb1547. Epub 2007 Feb 4.
5
Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1.在小鼠中对mTORC组分雷帕霉素靶蛋白结合蛋白（raptor）、rictor或mLST8进行基因敲除后发现，mTORC2对于Akt-FOXO和蛋白激酶Cα（PKCalpha）的信号传导是必需的，但对于核糖体蛋白S6激酶1（S6K1）的信号传导则不是必需的。
Dev Cell. 2006 Dec;11(6):859-71. doi: 10.1016/j.devcel.2006.10.007.
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Perturbations of the AKT signaling pathway in human cancer.人类癌症中AKT信号通路的扰动。
Oncogene. 2005 Nov 14;24(50):7455-64. doi: 10.1038/sj.onc.1209085.
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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.rictor-mTOR复合物对Akt/PKB的磷酸化及调控
Science. 2005 Feb 18;307(5712):1098-101. doi: 10.1126/science.1106148.
8
Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase.鉴定一种PKB/Akt疏水基序丝氨酸473激酶为DNA依赖性蛋白激酶。
J Biol Chem. 2004 Sep 24;279(39):41189-96. doi: 10.1074/jbc.M406731200. Epub 2004 Jul 15.
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Ten years of protein kinase B signalling: a hard Akt to follow.蛋白激酶B信号传导的十年：难以追踪的Akt
Trends Biochem Sci. 2001 Nov;26(11):657-64. doi: 10.1016/s0968-0004(01)01958-2.
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Discovery of PDK1, one of the missing links in insulin signal transduction. Colworth Medal Lecture.发现蛋白激酶 D1（PDK1），胰岛素信号转导中缺失的环节之一。科尔沃思奖章讲座。
Biochem Soc Trans. 2001 May;29(Pt 2):1-14. doi: 10.1042/0300-5127:0290001.

PI3K-PKB/Akt 通路。

PI3K-PKB/Akt pathway.

机构信息

Friedrich Miescher Institute for Biomedical Research, Basel 4058, Switzerland.

出版信息

Cold Spring Harb Perspect Biol. 2012 Sep 1;4(9):a011189. doi: 10.1101/cshperspect.a011189.

DOI:10.1101/cshperspect.a011189
PMID:22952397
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3428770/
Abstract

Protein kinase B (PKB, or Akt) plays a role in cell metabolism, growth, proliferation, and survival. Its activation is controlled by a multi-step process that involves phosphoinositide-3-kinase (PI3K).

摘要

蛋白激酶 B（PKB，也称为 Akt）在细胞代谢、生长、增殖和存活中发挥作用。其激活受多步过程控制，涉及磷酸肌醇-3-激酶（PI3K）。