University of California Los Angeles, Los Angeles, California, United States of America.
PLoS One. 2012;7(8):e43405. doi: 10.1371/journal.pone.0043405. Epub 2012 Aug 29.
Children with cleft lip and palate (CLP) are known to have airway problems. Previous studies have shown that individuals with CLP have a 30% reduction in nasal airway size compared to non-cleft controls. No reports have been found on cross-sectional area and volume of the pharyngeal airway in clefts. Introduction of Cone-Beam CT (CBCT) and imaging software has facilitated generation of 3D images for assessment of the cross-sectional area and volume of the airway.
To assess the pharyngeal airway in individuals with CLP using CBCT by measuring volume and smallest cross-sectional areas and compare with 19 age- and sex-matched non-cleft controls.
Retrospective study of CBCT data of pre-adolescent individuals (N = 19, Mean age = 10.6, 7 females, 12 males, UCLP = 6, BCLP = 3) from the Center for Craniofacial Anomalies. Volumetric analysis was performed using image segmentation features in CB Works 3.0. Volume and smallest cross-sectional were studied in both groups. Seven measurements were repeated to verify reliability using Pearson correlation coefficient. Volume and cross-sectional area differences were analyzed using paired t-tests.
The method was found to be reliable. Individuals with CLP did not exhibit smaller total airway volume and cross sectional area than non-CLP controls.
3D imaging using CBCT and CB Works is reliable for assessing airway volume. Previous studies have shown that the nasal airway is restricted in individuals with CLP. In our study, we found that the pharyngeal airway is not compromised in these individuals.
患有唇腭裂（CLP）的儿童已知存在气道问题。先前的研究表明，与非裂隙对照组相比，CLP 个体的鼻气道尺寸减小了 30%。目前尚无关于裂隙患者咽气道横截面积和体积的报告。锥形束 CT（CBCT）和成像软件的引入促进了气道横截面积和体积的 3D 图像生成，以进行评估。
使用 CBCT 通过测量体积和最小横截面积来评估 CLP 个体的咽气道，并与 19 名年龄和性别匹配的非裂隙对照组进行比较。
对来自颅面畸形中心的青少年前个体（N = 19，平均年龄 10.6，7 名女性，12 名男性，UCLP = 6，BCLP = 3）的 CBCT 数据进行回顾性研究。使用 CB Works 3.0 中的图像分割功能进行容积分析。在两组中都研究了体积和最小横截面积。使用 Pearson 相关系数重复了七次测量以验证可靠性。使用配对 t 检验分析体积和横截面积差异。
该方法被证明是可靠的。CLP 个体的总气道体积和横截面积并不小于非 CLP 对照组。
使用 CBCT 和 CB Works 的 3D 成像对于评估气道体积是可靠的。先前的研究表明，CLP 个体的鼻气道受到限制。在我们的研究中，我们发现这些个体的咽气道没有受到影响。
