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干扰素β-1a改善了一名HAM/TSP患者的泌尿症状，降低了前病毒载量，并改变了免疫反应。

Interferon Beta-1a Improves Urinary Symptoms, Reduces Proviral Load, and Modifies the Immune Response in a Patient with HAM/TSP.

作者信息

Costa Davi Tanajura, Sundberg Michael, Passos Lúcia, Muniz André Luiz, Santos Silvane

机构信息

Serviço de Imunologia, Hospital Universitário Prof. Edgard Santos, 5 Andar, Rua João das Botas S/N, Canela, 40110-160 Salvador, BA, Brazil.

出版信息

Case Rep Neurol Med. 2012;2012:958786. doi: 10.1155/2012/958786. Epub 2012 Aug 16.

DOI:10.1155/2012/958786
PMID:22953092
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3431060/
Abstract

The human T-cell lymphotropic virus type 1 (HTLV-1) is the known causative agent of a chronic neurologic condition known as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Although several therapies have been evaluated for HAM/TSP, none have been approved for use in humans. In this paper, we describe a 55-year-old female patient with HAM/TSP who was treated with interferon beta-1a. This patient, in comparison to 20 female patients with HAM/TSP who were not treated, showed improvement in urinary symptoms over four years of therapy, as well as a reduction in HTLV-1 proviral load and serum cytokine levels typically observed in HAM/TSP. This improved outcome merits further controlled studies on the use and efficacy of interferon beta-1a as a therapy for HAM/TSP.

摘要

人类嗜T淋巴细胞病毒1型（HTLV-1）是一种慢性神经疾病——HTLV-1相关脊髓病/热带痉挛性截瘫（HAM/TSP）的已知致病因子。尽管已经对几种治疗HAM/TSP的疗法进行了评估，但尚无一种被批准用于人类。在本文中，我们描述了一名55岁患HAM/TSP的女性患者，她接受了β-1a干扰素治疗。与20名未接受治疗的患HAM/TSP的女性患者相比，该患者在四年的治疗中尿路症状有所改善，同时HTLV-1前病毒载量以及HAM/TSP中通常观察到的血清细胞因子水平也有所降低。这一改善结果值得对β-1a干扰素作为HAM/TSP治疗方法的使用和疗效进行进一步的对照研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f325/3431060/6a97769ce861/CRIM.NM2012-958786.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f325/3431060/eb9d37ac9492/CRIM.NM2012-958786.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f325/3431060/6a97769ce861/CRIM.NM2012-958786.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f325/3431060/eb9d37ac9492/CRIM.NM2012-958786.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f325/3431060/6a97769ce861/CRIM.NM2012-958786.002.jpg

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2
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Folia Neuropathol. 2009;47(2):182-94.
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