Univ. Bordeaux, Neurocentre Magendie, Physiopathologie de la plasticité neuronale, U862, F-33000 Bordeaux, France.
Food Chem. 2012 Dec 1;135(3):1104-11. doi: 10.1016/j.foodchem.2012.03.135. Epub 2012 May 22.
Glycitein is a Selective Estradiol Receptor Modulator (SERM) from soy. The study reports plasma bioavailability and urine excretion of glycitein compared to other soy isoflavones after a unique intake of food supplement based on soy germ containing 55.24mg isoflavones. Eighteen plasma and urinary sampling profiles collected over 48h from healthy young Caucasian men were analysed using specific ELISAs. Eight profiles contained equol. Glycitein T(max), C(max), AUC(0→24h) and T(½) in plasma were calculated. Urine T(max), % of excretion at 24h and clearance were assessed. Glycitein is one of the best absorbed flavonoids. Plasma steady-state level can be achieved by several intakes a day. Glycitein bioavailability is similar to that of daidzein and its urinary excretion is significantly higher than that of genistein. Equol does not affect glycitein bioavailability. Knowing glycitein bioavailability in man is essential for the development of soy-germ-based food supplements for health applications.
染料木黄酮是一种来自大豆的选择性雌激素受体调节剂（SERM）。该研究报告了在摄入基于大豆胚芽的特殊食物补充剂（含 55.24mg 异黄酮）后，与其他大豆异黄酮相比，染料木黄酮的血浆生物利用度和尿液排泄情况。从 18 名健康的年轻白种男性收集了 48 小时内的 18 个血浆和尿液样本，使用特定的 ELISA 进行了分析。8 个样本中含有黄豆苷元。计算了染料木黄酮在血浆中的 T(max)、C(max)、AUC(0→24h)和 T(½)。评估了尿液 T(max)、24 小时排泄率和清除率。染料木黄酮是吸收最好的类黄酮之一。通过每天多次摄入可以达到血浆稳态水平。染料木黄酮的生物利用度与大豆苷元相似，其尿液排泄量明显高于染料木黄酮。黄豆苷元不会影响染料木黄酮的生物利用度。了解染料木黄酮在人体内的生物利用度对于开发基于大豆胚芽的食物补充剂以用于健康应用至关重要。
