Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus, Kannapolis, NC 28081, USA.
Food Chem. 2012 Dec 1;135(3):1659-66. doi: 10.1016/j.foodchem.2012.06.034. Epub 2012 Jun 28.
The effect of water soluble polyphenolic extract of peanut skin (PE) was investigated for its hypolipidemic properties in rats on Western diet. Seven-weeks old Wistar rats received control diet (AIN-93G), Western diet with and without a bolus of PE five times a week for 10weeks. Group which received 300mg/kg body weight showed significantly reduced body weight and epididymal fat. Plasma and liver triglyceride (TG) and cholesterol (TC) levels were significantly reduced while faecal secretion of TG and TC was greatly increased upon PE administration. Liver mRNA expression of enzymes involved in fatty acid synthesis, such as fatty acid synthase (FAS), sterol receptor element binding protein (SREBP)-1c, acetyl-CoA carboxylase (ACC1) and lipid uptake genes, such as PPARγ, were decreased, while PPARα was up-regulated by administration of PE. These data suggest that administration of PE may contribute to the improved lipid homoeostasis in rats on diets high in cholesterol and lipids.
研究了花生皮水溶性多酚提取物（PE）对高脂饮食大鼠的降血脂作用。7 周龄 Wistar 大鼠给予对照饮食（AIN-93G）、含和不含每周 5 次 PE 冲击剂量的高脂饮食 10 周。给予 300mg/kg 体重的组显示体重和附睾脂肪显著降低。PE 给药后，血浆和肝脏甘油三酯（TG）和胆固醇（TC）水平显著降低，而 TG 和 TC 的粪便分泌量大大增加。肝脏参与脂肪酸合成的酶，如脂肪酸合酶（FAS）、固醇受体元件结合蛋白（SREBP）-1c、乙酰辅酶 A 羧化酶（ACC1）和脂质摄取基因，如 PPARγ 的 mRNA 表达减少，而 PPARα 则被 PE 上调。这些数据表明，PE 的给药可能有助于改善高胆固醇和脂质饮食大鼠的脂质动态平衡。
