Department of Clinical Surgery, University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, UK.
HPB (Oxford). 2012 Oct;14(10):700-8. doi: 10.1111/j.1477-2574.2012.00521.x.
The aim of this prospective study was to investigate the implementation of an enhanced recovery after surgery (ERAS) programme following pancreaticoduodenectomy (PD).
Patients undergoing PD were managed according to an ERAS protocol. Outcome measures included postoperative mortality, morbidity, hospitalization and 30-day readmission rate. Key protocol targets were: nasogastric tube (NGT) removal [postoperative day (PoD) 1]; resumption of oral fluids (PoD 1); urinary catheter removal (PoD 3); high-dependency unit (HDU) discharge (PoD 3); tolerating diet (PoD 4); drain removal (PoD 5), and hospital discharge (PoD 6).
Data were collected for 50 patients (24 male; median age 67 years). Rates of mortality, morbidity and readmission were 4%, 46% and 4%, respectively. The median length of postoperative hospitalization was 10 days. The proportions of patients achieving key targets were: 78% for NGT removal; 82% for resumption of oral fluids; 48% for urinary catheter removal; 82% for HDU discharge; 86% for tolerating diet; 84% for meeting mobility targets, and 72% for drain removal. One patient was discharged by PoD 6, eight patients by PoD 7, 15 patients by PoD 8 and 26 patients (52%) by PoD 10. Discharge was delayed in 16 patients for social or transport-related reasons.
The ERAS protocol was implemented safely. Achieving certain targets was challenging. Non-medical causes remain a significant factor in delayed discharge following PD.
本前瞻性研究旨在调查胰腺十二指肠切除术(PD)后实施强化术后康复(ERAS)方案的情况。
根据 ERAS 方案对接受 PD 的患者进行管理。观察指标包括术后死亡率、发病率、住院时间和 30 天再入院率。关键方案目标为:拔除鼻胃管(术后第 1 天);开始口服液体(术后第 1 天);拔除导尿管(术后第 3 天);高依赖病房(HDU)出院(术后第 3 天);开始经口饮食(术后第 4 天);拔除引流管(术后第 5 天)和出院(术后第 6 天)。
共收集了 50 例患者(24 例男性;中位年龄 67 岁)的数据。死亡率、发病率和再入院率分别为 4%、46%和 4%。术后住院时间中位数为 10 天。达到关键目标的患者比例为:78%拔除鼻胃管;82%开始口服液体;48%拔除导尿管;82%HDU 出院;86%经口饮食;84%达到活动目标,72%拔除引流管。1 名患者术后第 6 天出院,8 名患者术后第 7 天出院,15 名患者术后第 8 天出院,26 名患者(52%)术后第 10 天出院。16 名患者因社会或交通相关原因而延迟出院。
ERAS 方案安全实施。达到某些目标具有挑战性。非医疗原因仍然是 PD 后延迟出院的一个重要因素。